Mortality of Adult Critically Ill Subjects With Cancer.
BACKGROUND: Cancer patients may require intensive care support for postoperative care, complications associated with underlying malignancy, or toxicities related to cancer therapy. The higher mortality rates found in this population than in the population of ICU patients without cancer may be attrib...
| Published in: | Respiratory Care Vol. 62; no. 5; pp. 615 - 623 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Mary Ann Liebert, Inc.
May2017
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122802981&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122802981 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: May2017 vid: 62 iid: 5 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 122802981 122802981 122802981 10.4187/respcare.05210 122802981 ppf: 615 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Mortality of Adult Critically Ill Subjects With Cancer. aug: au: Goulart Rosa, Regis Tonietto, Tulio Frederico Achutti Duso, Bruno Gasparetto Maccari, Juçara Rutzen, William Madeira, Laura Ascoli, Aline Hessler, Rachel Morandi, Paola Cremonese, Ricardo Viegas Dexheimer Neto, Felippe Leopoldo Tagliari, Luciana de Campos Balzano, Patrícia Teixeira, José Hervê Diel Barth ;Cassiano Pinheiro de Oliveira, Roselaine affil: ICU, Hospital Moinhos de Vento, Porto Alegre, Brazil sug: subj: Critically Ill Patients Cancer Patients Hospital Mortality Intensive Care Units Human Descriptive Statistics Retrospective Design Brazil Adult P-Value Probability Survival Analysis Comparative Studies Kaplan-Meier Estimator Chi Square Test Data Analysis Software Male Female Aged, 80 and Over Aged Middle Age Log-Rank Test Multiple Logistic Regression Confidence Intervals Odds Ratio Post Hoc Analysis APACHE (Acute Physiology and Chronic Health Evaluation) Clinical Assessment Tools Adult: 19-44 years Aged, 80 & over Aged: 65+ years Middle Aged: 45-64 years Male Female ab: BACKGROUND: Cancer patients may require intensive care support for postoperative care, complications associated with underlying malignancy, or toxicities related to cancer therapy. The higher mortality rates found in this population than in the population of ICU patients without cancer may be attributable to confounding due to a higher prevalence of multiple organic dysfunctions at ICU admission in patients with malignancy; however, data regarding this hypothesis are scarce. Accordingly, we performed the present study to compare the crude and propensity score-matched mortality rates between adult subjects with and without cancer admitted to a mixed medicalsurgical ICU. METHODS: We conducted a retrospective analysis of a comprehensive longitudinal ICU database in a tertiary referral hospital in Southern Brazil. All adult subjects who were admitted to the ICU from January 2008 to December 2014 were evaluated. Crude and propensity score-matched all-cause 30-d mortality rates of critically ill subjects with cancer were compared with those of critically ill subjects without cancer. RESULTS: A total of 4,221 subjects were evaluated. The survival analysis revealed that the crude mortality rate was higher among subjects with cancer than among subjects without cancer (18.7% vs 10.2%, P < .001). However, after matching by propensity score, the 30-d mortality rates of subjects with and without cancer were similar (18.5% vs 15.2%, P = .17). CONCLUSIONS: The present study failed to show an association between malignancy and all-cause 30-d mortality rate in adult subjects admitted to a mixed medical-surgical ICU. The propensity score-matched analysis showed no evidence of excessive mortality due to cancer diagnosis. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|