Longitudinal assessment of local and global functional connectivity following sports-related concussion.
Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state...
| Published in: | Brain Imaging & Behavior Vol. 11; no. 1; pp. 129 - 141 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Feb2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122834677&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122834677 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2017 vid: 11 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122834677 122834677 NLM26821253 122834677 10.1007/s11682-016-9520-y NLM26821253 122834677 ppf: 129 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Longitudinal assessment of local and global functional connectivity following sports-related concussion. aug: au: Meier, Timothy Bellgowan, Patrick Mayer, Andrew Meier, Timothy B Bellgowan, Patrick S F Mayer, Andrew R affil: National Institute of Neurological Disorders and Stroke , National Institutes of Health , North Bethesda MD 20892 USA sug: subj: Brain Physiopathology Brain Concussion Physiopathology Brain Concussion Etiology Athletic Injuries Physiopathology Relaxation Athletic Injuries Diagnosis, Neurologic Male Young Adult Students Prospective Studies Colleges and Universities Cross Sectional Studies Athletes Female Brain Brain Concussion Human Male Female ab: Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state functional connectivity using metrics that do not require a priori seed or network selection (regional homogeneity; ReHo and global brain connectivity; GBC, respectively). A large sample of collegiate athletes (N = 43) was assessed approximately one day (1.74 days post-injury, N = 34), one week (8.44 days, N = 34), and one month post-concussion (32.47 days, N = 30). Healthy contact sport-athletes served as controls (N = 51). Concussed athletes showed improvement in mood symptoms at each time point (p's < 0.05), but had significantly higher mood scores than healthy athletes at every time point (p's < 0.05). In contrast, self-reported symptoms and cognitive deficits improved over time following concussion (p's < 0.001), returning to healthy levels by one week post-concussion. ReHo in sensorimotor, visual, and temporal cortices increased over time post-concussion, and was greatest at one month post-injury. Conversely, ReHo in the frontal cortex decreased over time following SRC, with the greatest decrease evident at one month post-concussion. Differences in ReHo relative to healthy athletes were primarily observed at one month post-concussion rather than the more acute time points. Contrary to our hypothesis, no significant cross-sectional or longitudinal differences in GBC were observed. These results are suggestive of a delayed onset of local connectivity changes following SRC. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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