Aberrant regional homogeneity of resting-state executive control, default mode, and salience networks in adult patients with moyamoya disease.
Aberrant local connectivity within cerebral intrinsic connectivity networks (ICNs) at rest has not been reported in adult moyamoya disease (MMD). Our aim was to examine the regional homogeneity (ReHo) of executive control (ECN), default mode (DMN), and salience networks (SN) in patients with executi...
| Publicado en: | Brain Imaging & Behavior Vol. 11; no. 1; pp. 176 - 185 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122834679&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122834679 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2017 vid: 11 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122834679 122834679 NLM26843005 122834679 10.1007/s11682-016-9518-5 NLM26843005 122834679 ppf: 176 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Aberrant regional homogeneity of resting-state executive control, default mode, and salience networks in adult patients with moyamoya disease. aug: au: Lei, Yu Su, Jiabin Jiang, Hanqiang Guo, Qihao Ni, Wei Yang, Heng Gu, Yuxiang Mao, Ying affil: Department of Neurosurgery , Huashan Hospital of Fudan University , Wulumuqi Zhong Road 12 Shanghai 200040 China sug: subj: Moyamoya Disease Physiopathology Executive Function Brain Physiopathology Moyamoya Disease Psychosocial Factors Male Relaxation Neural Pathways Physiopathology Female Magnetic Resonance Imaging Moyamoya Disease Adult Neural Pathways Neuropsychological Tests Brain Human Adult: 19-44 years Male Female ab: Aberrant local connectivity within cerebral intrinsic connectivity networks (ICNs) at rest has not been reported in adult moyamoya disease (MMD). Our aim was to examine the regional homogeneity (ReHo) of executive control (ECN), default mode (DMN), and salience networks (SN) in patients with executive dysfunction to explore the underlying mechanism. Twenty-six adult patients with MMD and 24 normal control (NC) subjects were recruited. Executive function was evaluated by Trail Making Test Part B (TMT-B) and executive subtests of Memory and Executive Screening (MES-EX). Compared with NC, the case group exhibited ReHo decrease mainly in the frontal and parietal gyrus, and increase only in the left middle temporal gyrus. Subsequent ICNs analysis indicated that compared with NC, patients with MMD exhibited significantly decreased ReHo in the dorsolateral prefrontal cortex (DLPFC) and inferior parietal gyrus (IPG) of left ECN; the IPG, superior frontal gyrus, and DLPFC of the right ECN; the right precuneus, left medial superior frontal gyrus, and right medial orbitofrontal gyrus of the DMN; as well as the left middle frontal gyrus and right supplemental motor area of SN. When referring to the Suzuki's 6-stage classification, a trend of ReHo decrease with disease severity was observed in all of the ICNs examined, but only bilateral ECNs reached statistical significance. Finally, only bilateral ECNs exhibited a significant correlation of averaged ReHo values with executive performance. Our results provide new insight into the pathophysiology of adult MMD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|