'Waiting impulsivity' in isolation-reared and socially-reared rats: effects of amphetamine.
Background: Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. Methods:...
| Publicado en: | Psychopharmacology Vol. 234; no. 9/10; pp. 1587 - 1602 |
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| Autores principales: | , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
May2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122897810&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122897810 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: May2017 vid: 234 iid: 9/10 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 122897810 144076638 10.1007/s00213-017-4579-8 122897810 ppf: 1587 ppct: 15 formats: fmt: @attributes: type: P tig: atl: 'Waiting impulsivity' in isolation-reared and socially-reared rats: effects of amphetamine. aug: au: Liu, Yia-Ping Wilkinson, Lawrence Robbins, Trevor affil: Behavioural Genetics Group, Schools of Psychology & Medicine, Neuroscience and Mental Health Research Institute , Cardiff University , Cardiff CF10 3AT UK sug: ab: Background: Rats reared in social isolation exhibit various cognitive and behavioural abnormalities in adulthood. However, impulsivity following this treatment still remains unclear, especially in response to medications used in attention deficit hyperactivity disorder, such as amphetamine. Methods: Using an isolation-rearing (IR) manipulation, the present study examined the effects of IR on impulsive action and impulsive choice when also treated with doses of d-amphetamine, by employing the five-choice serial reaction time task (5-CSRTT) and a temporal discounting of reward task (TDRT), respectively. Results: IR rats showed similar acquisition of the 5-CSRTT. Amphetamine increased premature responding in both groups; however, IR rats showed less responding overall. For the TDRT, IR rats revealed a greater preference for the large but delayed reward during task acquisition (i.e. were less impulsive) with a higher rate of nose poking during the delay, and exhibited a compressed dose-response function (i.e. reduced dose sensitivity) for amphetamine. Discussion: Impulsive action and impulsive choice were reduced in IR rats under certain conditions, and a blunted response to d-amphetamine was found on these measures. These reductions in impulsivity contrast with locomotor hyperactivity normally shown in IR rats and the findings have implications for the utility of IR as a model of psychopathology. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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