Body composition and bone health in adolescents after Roux-en-Y gastric bypass for severe obesity.
Background Laparoscopic Roux-en-Y gastric bypass (RYGB) causes changes in body composition and bone metabolism, yet little is known about effects in adolescents. Objectives The objective of this study was to report dual-energy X-ray absorptiometry measures and serum bone markers, hypothesizing that...
| Publicado en: | Pediatric Obesity Vol. 12; no. 3; pp. 239 - 247 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122899631&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122899631 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20476302 ETV7 jtl: Pediatric Obesity issn: 20476302 maglogo: Y pubinfo: dt: Jun2017 vid: 12 iid: 3 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 122899631 122899631 122899631 10.1111/ijpo.12134 122899631 ppf: 239 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Body composition and bone health in adolescents after Roux-en-Y gastric bypass for severe obesity. aug: au: Beamish, A. J. Gronowitz, E. Olbers, T. Flodmark, C.‐E. Marcus, C. Dahlgren, J. affil: Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, the University of Gothenburg, Gothenburg Sweden sug: subj: Pediatric Obesity Body Composition In Adolescence Bone and Bones In Adolescence Anastomosis, Roux-en-Y Gastric Bypass Human Adolescence Surgery, Laparoscopic Absorptiometry, Photon Body Mass Index Obesity Male Female Descriptive Statistics Data Analysis Software Adolescent: 13-18 years Male Female ab: Background Laparoscopic Roux-en-Y gastric bypass (RYGB) causes changes in body composition and bone metabolism, yet little is known about effects in adolescents. Objectives The objective of this study was to report dual-energy X-ray absorptiometry measures and serum bone markers, hypothesizing that bone turnover increases after surgery. Methods Inclusion criteria included the following: age 13-18 years and body mass index (BMI) >35 kg/m2. Seventy-two adolescents (22 boys; mean age 16.5 years; BMI 44.8 kg/m2) undergoing RYGB underwent dual-energy X-ray absorptiometry and serum bone marker analyses preoperatively and annually for 2 years. Results Mean BMI reduction at 2 years was 15.1 kg/m2. Body composition changes included a reduction in fat mass (51.8% to 39.6%, p < 0.001) and relative increase in lean mass (47.0% to 58.1%, p < 0.001). In contrast to previous studies in adults, adolescent boys lost a greater percentage of their body fat than girls (−17.3% vs. −9.5%, p < 0.001). Individual bone mineral density Z-scores (BMD-Z) at baseline were within or above the normal range. The mean (SD) BMD-Z was 2.02 (1.2) at baseline, decreasing to 0.52 (1.19) at 2 years. Higher concentrations of serum CTX ( p < 0.001) and osteocalcin ( p < 0.001) were observed in boys throughout the study period. Levels rose in the first year, before decreasing modestly in the second. Levels of serum markers of bone synthesis and resorption were higher in boys, whose skeletal maturity occurs later than girls'. Conclusions Differences in body fat and lean mass proportions were observed according to sex following RYGB. Bone turnover increased, and BMD decreased to levels approaching a norm for age. Long-term outcome will determine the clinical relevance. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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