Pharmacokinetics and pharmacogenetics of the MEK1/2 inhibitor, selumetinib, in Asian and Western healthy subjects: a pooled analysis.

Purpose: Emerging data on selumetinib, a MEK1/2 inhibitor in clinical development, suggest a possible difference in pharmacokinetics (PK) between Japanese and Western patients. This pooled analysis sought to assess the effect of ethnicity on selumetinib exposure in healthy Western and Asian subjects...

Full description

Bibliographic Details

Published in:	European Journal of Clinical Pharmacology Vol. 73; no. 6; pp. 717 - 727
Main Authors:	Dymond, Angela, Elks, Cathy, Martin, Paul, Carlile, David, Mariani, Gabriella, Lovick, Susan, Huang, Yifan, Lorch, Ulrike, Brown, Helen, So, Karen
Format:	research tables/charts Journal Article
Published:	Springer Nature Jun2017
Online Access:	View this record in EBSCOhost