Analytical method for calculation of deviations from intended dosages during multi-infusion.
Background: In this paper, a new method is presented that combines mechanical compliance effects with Poiseuille flow and push-out effects ("dead volume") in one single mathematical framework for calculating dosing errors in multi-infusion set-ups. In contrast to existing numerical methods, our meth...
| Publicado en: | BioMedical Engineering OnLine Vol. 16; pp. 1 - 29 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
BioMed Central
1/17/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=122966885&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 122966885 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1475925X 1CGX jtl: BioMedical Engineering OnLine issn: 1475925X maglogo: N pubinfo: dt: 1/17/2017 vid: 16 pid: 24147 pub: BioMed Central artinfo: ui: 122966885 122966885 NLM28095851 10.1186/s12938-016-0309-4 NLM28095851 122966885 ppf: 1 ppct: 28 formats: tig: atl: Analytical method for calculation of deviations from intended dosages during multi-infusion. aug: au: Konings, Maurits K. Snijder, Roland A. Radermacher, Joris H. Timmerman, Annemoon M. affil: Department of Medical Technology and Clinical Physics, University Medical Center Utrecht, Room AZU - C.01.230, P.O. Box 85500, 3508 GA Utrecht, The Netherlands sug: subj: Infusion Pumps Rheology Equipment and Supplies Models, Theoretical Infusions, Intravenous Equipment and Supplies Drugs Catheters Sensitivity and Specificity Computer Simulation Reproducibility of Results Drug Combinations Rheology Methods Clinical Assessment Tools Scales ab: Background: In this paper, a new method is presented that combines mechanical compliance effects with Poiseuille flow and push-out effects ("dead volume") in one single mathematical framework for calculating dosing errors in multi-infusion set-ups. In contrast to existing numerical methods, our method produces explicit expressions that illustrate the mathematical dependencies of the dosing errors on hardware parameters and pump flow rate settings.Methods: Our new approach uses the Z-transform to model the contents of the catheter, and after implementation in Mathematica (Wolfram), explicit expressions are produced automatically. Consistency of the resulting analytical expressions has been examined for limiting cases, and three types of in-vitro measurements have been performed to obtain a first experimental test of the validity of the theoretical results.Results: The relative contribution of various factors affecting the dosing errors, such as the Poiseuille flow profile, resistance and internal volume of the catheter, mechanical compliance of the syringes and the various pump flow rate settings, can now be discerned clearly in the structure of the expressions generated by our method. The in-vitro experiments showed a standard deviation between theory and experiment of 14% for the delay time in the catheter, and of 13% for the time duration of the dosing error bolus.Conclusions: Our method provides insight and predictability in a large range of possible situations involving many variables and dependencies, which is potentially very useful for e.g. the development of a fast, bed-side tool ("calculator") that provides the clinician with a precise prediction of dosing errors and delay times interactively for many scenario's. The interactive nature of such a device has now been made feasible by the fact that, using our method, explicit expressions are available for these situations, as opposed to conventional time-consuming numerical simulations. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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