Advanced computational workflow for the multi-scale modeling of the bone metabolic processes.
Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale....
| Published in: | Medical & Biological Engineering & Computing Vol. 55; no. 6; pp. 923 - 934 |
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| Main Authors: | , |
| Format: | case study equations & formulas pictorial research tables/charts Journal Article |
| Published: |
Springer Nature
Jun2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123190309&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123190309 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jun2017 vid: 55 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123190309 123190309 144117452 NLM27638110 123190309 10.1007/s11517-016-1572-z NLM27638110 123190309 ppf: 923 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Advanced computational workflow for the multi-scale modeling of the bone metabolic processes. aug: au: Dao, Tien Dao, Tien Tuan affil: Sorbonne University, Université de Technologie de Compiègne , CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu , 60203 Compiègne Cedex France sug: subj: Bone and Bones Metabolism Bone and Bones Physiology Systems Analysis Stress, Mechanical Bone Remodeling Physiology Kinematics Physiology Computer Simulation Human ab: Multi-scale modeling of the musculoskeletal system plays an essential role in the deep understanding of complex mechanisms underlying the biological phenomena and processes such as bone metabolic processes. Current multi-scale models suffer from the isolation of sub-models at each anatomical scale. The objective of this present work was to develop a new fully integrated computational workflow for simulating bone metabolic processes at multi-scale levels. Organ-level model employs multi-body dynamics to estimate body boundary and loading conditions from body kinematics. Tissue-level model uses finite element method to estimate the tissue deformation and mechanical loading under body loading conditions. Finally, cell-level model includes bone remodeling mechanism through an agent-based simulation under tissue loading. A case study on the bone remodeling process located on the human jaw was performed and presented. The developed multi-scale model of the human jaw was validated using the literature-based data at each anatomical level. Simulation outcomes fall within the literature-based ranges of values for estimated muscle force, tissue loading and cell dynamics during bone remodeling process. This study opens perspectives for accurately simulating bone metabolic processes using a fully integrated computational workflow leading to a better understanding of the musculoskeletal system function from multiple length scales as well as to provide new informative data for clinical decision support and industrial applications. pubtype: Academic Journal doctype: case study equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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