Investigation of altered microstructure in patients with drug refractory epilepsy using diffusion tensor imaging.
Purpose: The risk of refractory epilepsy can be more dangerous than the adverse effect caused by medical treatment. In this study, we employed voxel-wise analysis (VWA) and tract-based spatial statistics (TBSS) methods to measure microstructural changes using diffusion tensor imaging (DTI) in patien...
| Publicado en: | Neuroradiology Vol. 59; no. 6; pp. 597 - 609 |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123281984&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123281984 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jun2017 vid: 59 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123281984 123281984 143910169 123281984 10.1007/s00234-017-1835-x 123281984 ppf: 597 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Investigation of altered microstructure in patients with drug refractory epilepsy using diffusion tensor imaging. aug: au: Jiang, Yuwei Mao, Lingyan Yan, Xu Fan, Mingxia Wang, Xin Ding, Jing Xu, Dongrong affil: Key Laboratory of Magnetic Resonance , East China Normal University , Shanghai People's Republic of China sug: subj: Epilepsy Language Disorders Diffusion Scanners Statistics Child Fisher's Exact Test Data Analysis, Statistical T-Tests Data Analysis Effect Size Scales Sensitivity and Specificity Child: 6-12 years ab: Purpose: The risk of refractory epilepsy can be more dangerous than the adverse effect caused by medical treatment. In this study, we employed voxel-wise analysis (VWA) and tract-based spatial statistics (TBSS) methods to measure microstructural changes using diffusion tensor imaging (DTI) in patients of drug refractory epilepsy (DRE) who had been epileptic for more than 10 years. Methods: To examine the specific microstructural abnormalities in DRE patients and its difference from medically controlled epilepsy (MCE), we acquired DTI data of 7 DRE patients, 37 MCE patients, and 31 healthy controls (HCs) using a 3 T MRI scanner. Comparisons between epileptic patients and HCs between MCE and DRE patients were performed based on calculated diffusion anisotropic indices data using VWA and TBSS. Results: Compared to HCs, epileptic patients (including MCE and DRE) showed significant DTI changes in the common affected regions based on VWA, whereas TBSS found that widespread DTI changes in parts of microstructures of bilateral hemispheres were more obvious in the DRE patients than that in the MCE patients when compared with HCs. In contrast, significant reduction of fractional anisotropy values of thalamo-cortical fibers, including left superior temporal gyrus, insular cortex, pre-/post-central gyri, and thalamus, were further found in DRE patients compared with MCE. Conclusion: The results of multiple diffusion anisotropic indices data provide complementary information to understand the dysfunction of thalamo-cortical pathway in DRE patients, which may be contributors to disorder of language and motor functions. Our current study may shed light on the pathophysiology of DRE. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|