Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment.
Objectives: To explore the changes of glutamate-glutamine (Glx) and gamma-aminobutyric acid (GABA) in the brain in normal old age and cognitive impairment using magnetic resonance spectroscopy (MRS).Methods: Seventeen normal young controls (NYC), 15 normal elderly controls (NEC), 21 patients with mi...
| Publicado en: | European Radiology Vol. 27; no. 7; pp. 2698 - 2706 |
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| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123476734&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123476734 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2017 vid: 27 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123476734 123476734 144096208 NLM27966041 123476734 10.1007/s00330-016-4669-8 NLM27966041 123476734 ppf: 2698 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment. aug: au: Huang, Dandan Liu, Dan Yin, Jianzhong Qian, Tianyi Shrestha, Susan Ni, Hongyan affil: Department of Radiology, First Central Clinical College , Tianjin Medical University , Tianjin 300070 China sug: subj: Limbic System Metabolism Alzheimer's Disease Metabolism GABA Metabolism Hippocampus Metabolism Glutamine Metabolism Glutamic Acid Metabolism Magnetic Resonance Imaging Early Diagnosis Aged Middle Age Female Male Case Control Studies Magnetic Resonance Spectroscopy Methods Young Adult Analysis of Variance Adult Aging Human Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: Objectives: To explore the changes of glutamate-glutamine (Glx) and gamma-aminobutyric acid (GABA) in the brain in normal old age and cognitive impairment using magnetic resonance spectroscopy (MRS).Methods: Seventeen normal young controls (NYC), 15 normal elderly controls (NEC), 21 patients with mild cognitive impairment (MCI) and 17 with Alzheimer disease (AD) patients were included in this study. Glx and GABA+ levels in the anterior cingulate cortex (ACC) and right hippocampus (rHP) were measured by using a MEGA-PRESS sequence. Glx/Cr and GABA+/Cr ratios were compared between NYC and NEC and between the three elderly groups using analysis of covariance (ANCOVA); the tissue fractions of voxels were used as covariates. The relationships between metabolite ratios and cognitive performance were analysed using Spearman correlation coefficients.Results: For NEC and NYC groups, Glx/Cr and GABA+/Cr ratios were lower in NEC in ACC and rHP. For the three elderly groups, Glx/Cr ratio was lower in AD in ACC compared to NEC and MCI; Glx/Cr ratio was lower in AD in rHP compared to NEC. There was no significant decrease for GABA+/Cr ratio.Conclusions: Glx and GABA levels may decrease simultaneously in normal aged, and Glx level decreased predominantly in AD, and it is helpful in the early diagnosis of AD.Key Points: • Glx and GABA levels may decrease simultaneously in normal aged. • Glx level may decrease predominantly in Alzheimer disease. • The balance in excitatory-inhibitory systems may be broken in AD. • Decreased Glx level may be helpful in early diagnosis of AD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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