Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis.
Purpose: To investigate hepatosplenic volumetry at MDCT for non-invasive prediction of hepatic fibrosis.Methods: Hepatosplenic volume analysis in 624 patients (mean age, 48.8 years; 311 M/313 F) at MDCT was performed using dedicated software and compared against pathological fibrosis stage (F0 = 374...
| Publicado en: | European Radiology Vol. 27; no. 7; pp. 3060 - 3069 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123476747&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123476747 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2017 vid: 27 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123476747 123476747 143968710 NLM27858212 10.1007/s00330-016-4648-0 NLM27858212 123476747 ppf: 3060 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Hepatosplenic volumetric assessment at MDCT for staging liver fibrosis. aug: au: Pickhardt, Perry Malecki, Kyle Hunt, Oliver Beaumont, Claire Kloke, John Ziemlewicz, Timothy Lubner, Meghan Pickhardt, Perry J Hunt, Oliver F Ziemlewicz, Timothy J Lubner, Meghan G affil: Department of Radiology , University of Wisconsin School of Medicine & Public Health , E3/311 Clinical Science Center, 600 Highland Ave. Madison 53792-3252 USA sug: subj: Liver Liver Cirrhosis Diagnosis Multidetector Computed Tomography Methods Spleen Retrospective Design Predictive Value of Tests Female Body Weights and Measures Prognosis Middle Age Biopsy Severity of Illness Indices Disease Progression Male Middle Aged: 45-64 years Female Male ab: Purpose: To investigate hepatosplenic volumetry at MDCT for non-invasive prediction of hepatic fibrosis.Methods: Hepatosplenic volume analysis in 624 patients (mean age, 48.8 years; 311 M/313 F) at MDCT was performed using dedicated software and compared against pathological fibrosis stage (F0 = 374; F1 = 48; F2 = 40; F3 = 65; F4 = 97). The liver segmental volume ratio (LSVR) was defined by Couinaud segments I-III over segments IV-VIII. All pre-cirrhotic fibrosis stages (METAVIR F1-F3) were based on liver biopsy within 1 year of MDCT.Results: LSVR and total splenic volumes increased with stage of fibrosis, with mean(±SD) values of: F0: 0.26 ± 0.06 and 215.1 ± 88.5 mm3; F1: 0.25 ± 0.08 and 294.8 ± 153.4 mm3; F2: 0.331 ± 0.12 and 291.6 ± 197.1 mm3; F3: 0.39 ± 0.15 and 509.6 ± 402.6 mm3; F4: 0.56 ± 0.30 and 790.7 ± 450.3 mm3, respectively. Total hepatic volumes showed poor discrimination (F0: 1674 ± 320 mm3; F4: 1631 ± 691 mm3). For discriminating advanced fibrosis (≥F3), the ROC AUC values for LSVR, total liver volume, splenic volume and LSVR/spleen combined were 0.863, 0.506, 0.890 and 0.947, respectively.Conclusion: Relative changes in segmental liver volumes and total splenic volume allow for non-invasive staging of hepatic fibrosis, whereas total liver volume is a poor predictor. Unlike liver biopsy or elastography, these CT volumetric biomarkers can be obtained retrospectively on routine scans obtained for other indications.Key Points: • Regional changes in hepatic volume (LSVR) correlate well with degree of fibrosis. • Total liver volume is a very poor predictor of underlying fibrosis. • Total splenic volume is associated with the degree of hepatic fibrosis. • Hepatosplenic volume assessment is comparable to elastography for staging fibrosis. • Unlike elastography, volumetric analysis can be performed retrospectively. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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