Restrictive allograft syndrome after lung transplantation: new radiological insights.
Objectives: To describe the CT changes in patients with restrictive allograft syndrome (RAS) after lung transplantation, before and after clinical diagnosis.Methods: This retrospective study included 22 patients with clinical diagnosis of RAS. Diagnosis was based on a combination of forced expirator...
| Published in: | European Radiology Vol. 27; no. 7; pp. 2810 - 2818 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Jul2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123476752&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123476752 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Jul2017 vid: 27 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123476752 123476752 144078667 NLM27878373 123476752 10.1007/s00330-016-4643-5 NLM27878373 123476752 ppf: 2810 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Restrictive allograft syndrome after lung transplantation: new radiological insights. aug: au: Dubbeldam, Adriana Barthels, Caroline Coolen, Johan Verschakelen, Johny Verleden, Stijn Vos, Robin Verleden, Geert Wever, Walter Verschakelen, Johny A Verleden, Stijn E Verleden, Geert M De Wever, Walter affil: Department of Radiology , University Hospitals Leuven , Herestraat 49 3000 Leuven Belgium sug: subj: Pulmonary Fibrosis Diagnosis Lung Graft Rejection Lung Transplantation Adverse Effects Tomography, X-Ray Computed Methods Retrospective Design Child Adult Survival Trends Syndrome Adolescence Young Adult Forced Expiratory Volume Male Time Factors Female Graft Survival Allografts Belgium Middle Age Respiratory Function Tests Pulmonary Fibrosis Mortality Prospective Studies Total Lung Capacity Disease Progression Pulmonary Fibrosis Etiology Human Child: 6-12 years Adult: 19-44 years Adolescent: 13-18 years Middle Aged: 45-64 years Male Female ab: Objectives: To describe the CT changes in patients with restrictive allograft syndrome (RAS) after lung transplantation, before and after clinical diagnosis.Methods: This retrospective study included 22 patients with clinical diagnosis of RAS. Diagnosis was based on a combination of forced expiratory volume (FEV1) decline (≥20 %) and total lung capacity (TLC) decline (≥10 %). All available CT scans after transplantation were analyzed for the appearance and evolution of lung abnormalities.Results: In 14 patients, non-regressing nodules and reticulations predominantly affecting the upper lobes developed an average of 13.9 months prior to the diagnosis of RAS. Median graft survival after onset of non-regressing abnormalities was 33.5 months, with most patients in follow-up (9/14). In eight patients, a sudden appearance of diffuse consolidations mainly affecting both upper and lower lobes was seen an average of 2.8 months prior to the diagnosis of RAS. Median graft survival was 6.4 months after first onset of non-regressing abnormalities, with graft loss in most patients (6/8).Conclusions: RAS has been previously described as a homogenous group. However, our study shows two different groups of RAS-patients: one with slow progression and one with fast progression. The two groups show different onset and progression patterns of CT abnormalities.Key Points: • RAS is the newest discovered form of chronic lung allograft dysfunction (CLAD). • RAS is not a homogenous group, as survival varies greatly between patients. • In this study, we see two different CT onset and progression patterns. • These two different CT patterns also correlate with a different survival rate. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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