Distinct Clinical Phenotypes of Occupational Asthma due to Diisocyanates.
Objective: To assess whether diisocyanate occupational asthma represents a unique phenotype. Methods: We studied 187 patients with diagnosis of asthma due to diisocyanates confirmed by a positive specific inhalation challenge. The simplified algorithm from severe asthma research program (SARP) (Moor...
| Publicado en: | Journal of Occupational & Environmental Medicine Vol. 59; no. 6; pp. 539 - 543 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Lippincott Williams & Wilkins
Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123553075&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123553075 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10762752 OEM jtl: Journal of Occupational & Environmental Medicine issn: 10762752 maglogo: N pubinfo: dt: Jun2017 vid: 59 iid: 6 pid: 433 pub: Lippincott Williams & Wilkins place: Baltimore, Maryland artinfo: ui: 123553075 123553075 123553075 10.1097/JOM.0000000000001017 123553075 ppf: 539 ppct: 4 formats: tig: atl: Distinct Clinical Phenotypes of Occupational Asthma due to Diisocyanates. aug: au: Mason, Paola Scarpa, Maria Cristina Liviero, Filippo Guarnieri, Gabriella Maestrelli, Piero affil: Department of Cardiologic, Thoracic and Vascular Sciences, University of Padova, Padova, Italy sug: subj: Asthma, Occupational Etiology Phenotype Asthma, Occupational Familial and Genetic Occupational Exposure Organic Chemicals Adverse Effects Human Algorithms Research Methodology ab: Objective: To assess whether diisocyanate occupational asthma represents a unique phenotype. Methods: We studied 187 patients with diagnosis of asthma due to diisocyanates confirmed by a positive specific inhalation challenge. The simplified algorithm from severe asthma research program (SARP) (Moore et al, 2010) was applied to classify patients into five clusters. Results: Our patients were allocated in three of the five clusters described in common asthma, since the most severe Clusters (4 and 5) were not represented. Cluster 2 was the most populated, as in common asthma, and included the youngest patients with the shortest duration of exposure to the sensitizers. Cluster 3 included older men patients with worse lung function and longer occupational exposure. Conclusions: Diisocyanate asthma is a heterogeneous disease. Differences across clusters include demographic characteristics, lung function, and chronology of diisocyanate exposure. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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