Optimizing 18F-FDG Uptake Time Before Imaging Improves the Accuracy of PET/CT in Liver Lesions.
Unlabelled: (18)F-FDG PET/CT has emerged as one of the fastest-growing imaging modalities. A shorter protocol results in a lower target-to-background ratio, which can increase the challenge of identifying mildly (18)F-FDG-avid lesions and differentiating inflammatory or physiologic activity from mal...
| Published in: | Journal of Nuclear Medicine Technology Vol. 44; no. 2; pp. 70 - 73 |
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| Main Authors: | , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Society of Nuclear Medicine
Jun2016
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123613687&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123613687 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00914916 H7Q jtl: Journal of Nuclear Medicine Technology issn: 00914916 maglogo: N pubinfo: dt: Jun2016 vid: 44 iid: 2 pid: 2576 pub: Society of Nuclear Medicine place: Reston, Virginia artinfo: ui: 123613687 123613687 NLM26966128 123613687 10.2967/jnmt.115.169953 NLM26966128 123613687 ppf: 70 ppct: 3 formats: fmt: @attributes: type: P tig: atl: Optimizing 18F-FDG Uptake Time Before Imaging Improves the Accuracy of PET/CT in Liver Lesions. aug: au: Al-Faham, Zaid Jolepalem, Prashant Rydberg, John Wong, Ching-Yee O. affil: Beaumont Health System, Royal Oak, Michigan. sug: subj: Liver Diseases Liver Diseases Metabolism Fludeoxyglucose F 18 Metabolism Male Aged, 80 and Over Biological Transport Female Adult Liver Time Factors Sensitivity and Specificity Image Processing, Computer Assisted Fludeoxyglucose F 18 Administration and Dosage Liver Metabolism Radioisotopes Aged Injections Middle Age Human Aged, 80 & over Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Unlabelled: (18)F-FDG PET/CT has emerged as one of the fastest-growing imaging modalities. A shorter protocol results in a lower target-to-background ratio, which can increase the challenge of identifying mildly (18)F-FDG-avid lesions and differentiating inflammatory or physiologic activity from malignant activity. The purpose of this study was to determine the delay between radiotracer injection and imaging that optimizes target-to-background ratio while maintaining counts high enough to ensure scan sensitivity.Methods: The study included 140 patients (66 male and 74 female; age range, 42-95 y) with suspected hepatic lesions as seen on an (18)F-FDG PET scan. SUV was determined as region-of-interest activity/(dose/total body weight).Results: The mean injected dose was 610 ± 66.6 MBq (16.5 ±1.8 mCi), with a mean glucose level of 107 ± 26.6 mg/dL (standardized to 90 mg/dL). The uptake time before imaging ranged from 61 to 158 min, with a mean of 108.8 ± 24.8 min. The P values for the correlation of SUV to time were 0.004, 0.003, and 0.0001 for malignant lesions, benign lesions, and background hepatic tissue, respectively.Conclusion: An approximately 90-min time window from (18)F-FDG injection to PET imaging would significantly improve target-to-background ratio and, thus, quantitation and visual interpretation. This benefit outweighs the minimal loss in patient throughput. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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