A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy.
Objectives: To investigate whether the evaluation of multiple spectral regions can increase the diagnostic performance of 1H-MRS of the breast and reduce false positive findings.Methods: 93 patients (mean age 56 years, range 23-79) undergoing breast MRI for routine clinical indications on a 1.5T sca...
| Published in: | European Journal of Radiology pp. 51 - 58 |
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| Main Authors: | , , , |
| Format: | research Journal Article |
| Published: |
Elsevier B.V.
Jul2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123629445&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123629445 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0720048X 3S7 jtl: European Journal of Radiology issn: 0720048X maglogo: N pubinfo: dt: Jul2017 pid: 1004 pub: Elsevier B.V. artinfo: ui: 123629445 123629445 NLM28624020 123629445 10.1016/j.ejrad.2017.04.014 NLM28624020 123629445 ppf: 51 ppct: 7 formats: tig: atl: A new method to reduce false positive results in breast MRI by evaluation of multiple spectral regions in proton MR-spectroscopy. aug: au: Clauser, Paola Marcon, Magda Dietzel, Matthias Baltzer, Pascal A.T. affil: Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, Austria sug: subj: Breast Neoplasms Choline Analysis Magnetic Resonance Imaging Methods Choline Breast Neoplasms Pathology Sensitivity and Specificity Radiography Protons Female Methane Prospective Studies Algorithms Water Pharmacokinetics Human Female ab: Objectives: To investigate whether the evaluation of multiple spectral regions can increase the diagnostic performance of 1H-MRS of the breast and reduce false positive findings.Methods: 93 patients (mean age 56 years, range 23-79) undergoing breast MRI for routine clinical indications on a 1.5T scanner were eligible for this IRB-approved prospective study. Suspicious enhancing lesions ≥8mm underwent single-voxel point-resolved 1H-MRS (PRESS, TR=2000ms, TE=272ms). Histology showed 69 malignant and 24 benign lesions. The Signal-to-Noise ratio of choline, olefinic acids and the water-to-methylene ratio were measured. The area under the ROC-curve (AUC) was used to evaluate single measurements. Combined diagnostic accuracy was explored using a 10-fold cross-validated Chi-squared automatic interaction detection (CHAID) analysis. Inter-reader agreement was evaluated in a subset of patients.Results: A significant AUC for differentiation between benign and malignant lesions was identified for choline (0.733, P=0.001), olefinic acids (0.769, P=0.0001) and water-to-methylene ratio (0.704, P=0.003). All three variables were included in a classification algorithm using CHAID methodology. Using this classification, 70.8% (17/24) false positive diagnoses in benign lesions would have been avoided. Inter-reader agreement was almost perfect.Conclusions: The combined evaluation of multiple spectral regions can increase the diagnostic performance of 1H-MRS and potentially reduce false positive findings. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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