The prognostic value of pre-diagnosis health-related quality of life on survival: a prospective cohort study of older Americans with lung cancer.
Purpose: Health-related quality of life (HRQOL) after cancer diagnosis is prognostic for overall survival (OS). However, no studies have assessed if HRQOL before diagnosis is predictive for OS. The objective of this study was to determine the association between pre-lung cancer diagnosis HRQOL and O...
| Published in: | Quality of Life Research Vol. 26; no. 7; pp. 1703 - 1713 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
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Springer Nature
Jul2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123691568&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123691568 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Jul2017 vid: 26 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123691568 123691568 143907262 NLM28194618 123691568 10.1007/s11136-017-1515-7 NLM28194618 123691568 ppf: 1703 ppct: 10 formats: fmt: @attributes: type: P tig: atl: The prognostic value of pre-diagnosis health-related quality of life on survival: a prospective cohort study of older Americans with lung cancer. aug: au: Pinheiro, Laura Zagar, Timothy Reeve, Bryce Pinheiro, Laura C Zagar, Timothy M Reeve, Bryce B affil: Department of Health Policy and Management, Gillings School of Global Public Health , University of North Carolina at Chapel Hill , Chapel Hill USA sug: subj: Activities of Daily Living Psychosocial Factors Quality of Life Psychosocial Factors Lung Neoplasms Psychosocial Factors Prospective Studies Aged Lung Neoplasms Mortality Aging Prognosis Male United States Female Aged, 80 and Over Survival Analysis Funding Source Human Aged: 65+ years Aged, 80 & over Male Female ab: Purpose: Health-related quality of life (HRQOL) after cancer diagnosis is prognostic for overall survival (OS). However, no studies have assessed if HRQOL before diagnosis is predictive for OS. The objective of this study was to determine the association between pre-lung cancer diagnosis HRQOL and OS.Methods: Our prospective cohort study used surveillance, epidemiology, and end results linked to the Medicare Health Outcomes Survey. We included 6290 individuals 65 years or older diagnosed with incident lung cancer from 1998 to 2013. We assessed the prognostic value of (1) short-form 36 summary component and domain-specific scores, (2) activities of daily living (ADL), and (3) two global HRQOL questions. Cox-proportional hazards models were used to examine associations between HRQOL and OS, adjusting for demographics, comorbid conditions, and clinical characteristics.Results: Worse pre-diagnosis HRQOL was significantly associated with greater risk of death across HRQOL measures. An above average physical or mental component summary score was associated with 16 and 24% decreases in the hazard of death, respectively (p < 0.0001). Being unable to perform ADLs, such as bathing oneself, was associated with an 89% increased hazard of death (p < 0.0001). Reporting "poor" versus "excellent" health was associated with a 74% increase in the hazard of death (p < 0.0001).Conclusion: This population-based study reinforces the importance of self-reported health status as a predictor for OS. Routine HRQOL screening may identify patients who could benefit from early interventions to improve HRQOL. Future studies should explore associations between changes in HRQOL before and after cancer diagnosis and OS. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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