Sporadic occurrence of cryptococcal meningitis in HIV-seronegative patients: Uncommon etiology?
Cryptococcosis in HIV-seronegative patients is rarely reported from India. This prospective study was conducted to look for cryptococcal meningitis in HIV-seronegative individuals and compare their laboratory features to cryptococcal meningitis in HIV-seropositive patients. Cerebrospinal fluid was c...
| Publicado en: | Indian Journal of Pathology & Microbiology Vol. 60; no. 2; pp. 236 - 239 |
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| Autores principales: | , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Apr-Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123711712&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123711712 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03774929 50DI jtl: Indian Journal of Pathology & Microbiology issn: 03774929 maglogo: N pubinfo: dt: Apr-Jun2017 vid: 60 iid: 2 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 123711712 123711712 NLM28631642 123711712 10.4103/IJPM.IJPM_599_16 NLM28631642 123711712 ppf: 236 ppct: 3 formats: tig: atl: Sporadic occurrence of cryptococcal meningitis in HIV-seronegative patients: Uncommon etiology? aug: au: Das, Shukla Datt, Shyama Roy, Priyamvada Saha, Rumpa Xess, Immaculata affil: Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, New Delhi, India sug: subj: Meningitis, Cryptococcal Epidemiology Cryptococcus Female Fluconazole Pharmacodynamics Cerebrospinal Fluid Microbiology Aged Human Young Adult India Antifungal Agents Pharmacodynamics Amphotericin B Pharmacodynamics Adolescence Middle Age Prospective Studies Adult Child, Preschool Microbial Culture and Sensitivity Tests Cryptococcus Drug Effects Prevalence HIV Infections Complications Male Child Validation Studies Comparative Studies Evaluation Research Multicenter Studies Aged: 65+ years Adolescent: 13-18 years Middle Aged: 45-64 years Adult: 19-44 years Child, Preschool: 2-5 years Child: 6-12 years Female Male ab: Cryptococcosis in HIV-seronegative patients is rarely reported from India. This prospective study was conducted to look for cryptococcal meningitis in HIV-seronegative individuals and compare their laboratory features to cryptococcal meningitis in HIV-seropositive patients. Cerebrospinal fluid was collected from 153 suspected cases of meningitis and subjected to India ink preparation, antigen detection, and culture. Nineteen samples tested positive for Cryptococcus neoformans infection. Seventeen and two patients were HIV reactive and nonreactive, respectively. In vitro susceptibility of C. neoformans isolates to fluconazole and amphotericin B was performed using standard broth microdilution method and E-test. Eighteen strains were susceptible to amphotericin B, while fluconazole was reported susceptible in 15 strains. Hence, index of suspicion of C. neoformans infection as possible cause of meningitis must be maintained even in HIV-negative patients. Use of amphotericin B for treating C. neoformans meningitis should be restricted to prevent any increase in resistance. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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