Bone marrow fat content in 70 adolescent girls with anorexia nervosa: Magnetic resonance imaging and magnetic resonance spectroscopy assessment.
Background: Adolescents and women with anorexia nervosa have increased bone marrow fat and decreased bone formation, at least in part due to hormonal changes leading to preferential stem cell differentiation to adipocytes over osteoblasts.Objective: The purpose of this study was to evaluate marrow f...
| Publicado en: | Pediatric Radiology Vol. 47; no. 8; pp. 952 - 963 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Jul2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123773555&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123773555 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Jul2017 vid: 47 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123773555 123773555 143926038 NLM28432403 123773555 10.1007/s00247-017-3856-3 NLM28432403 123773555 ppf: 952 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Bone marrow fat content in 70 adolescent girls with anorexia nervosa: Magnetic resonance imaging and magnetic resonance spectroscopy assessment. aug: au: Ecklund, Kirsten Vajapeyam, Sridhar Mulkern, Robert Feldman, Henry O'Donnell, Jennifer DiVasta, Amy Gordon, Catherine Mulkern, Robert V Feldman, Henry A O'Donnell, Jennifer M DiVasta, Amy D Gordon, Catherine M affil: Department of Radiology , Boston Children's Hospital , 333 Longwood Ave. Boston 02115 USA sug: subj: Magnetic Resonance Spectroscopy Methods Anorexia Nervosa Pathology Knee Magnetic Resonance Imaging Methods Adipose Tissue Anorexia Nervosa Bone Marrow Adipose Tissue Pathology Bone Marrow Pathology Female Age Factors Adolescence Severity of Illness Indices Child Funding Source Human Adolescent: 13-18 years Child: 6-12 years Female ab: Background: Adolescents and women with anorexia nervosa have increased bone marrow fat and decreased bone formation, at least in part due to hormonal changes leading to preferential stem cell differentiation to adipocytes over osteoblasts.Objective: The purpose of this study was to evaluate marrow fat content and correlate with age and disease severity using knee MRI with T1 relaxometry (T1-R) and MR spectroscopy (MRS) in 70 adolescents with anorexia nervosa.Materials and Methods: We enrolled 70 girls with anorexia nervosa who underwent 3-T knee MRI with coronal T1-W images, T1-R and single-voxel proton MRS at 30 and 60 ms TE. Metaphyses were scored visually on the T1-W images for red marrow. Visual T1 score, T1 relaxometry values, MRS lipid indices and fat fractions were analyzed by regression on age, body mass index (BMI) and bone mineral density (BMD) as disease severity markers. MRS measures included unsaturated fat index, T2 water, unsaturated and saturated fat fractions.Results: All red marrow measures declined significantly with age. T1-R values were associated negatively with BMI and BMD for girls ≤16 years (P=0.03 and P=0.002, respectively) and positively for those≥17 years (P=0.05 and P=0.003, respectively). MRS identified a strong inverse association between T2 water and saturated fat fraction from 60 ms TE data (r=-0.85, P<0.0001). There was no association between unsaturated fat index and BMI or BMD.Conclusions: The association between T1 and BMI and BMD among older girls suggests more marrow fat in those with severe anorexia nervosa. In contrast, the physiological association between marrow fat content and age remained dominant in younger patients. The strong association between T2 water and saturated fat may relate to the restricted mobility of water with increasing marrow fat. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|