Abnormal functional connectivity strength in patients with adolescent-onset schizophrenia: a resting-state fMRI study.
Structural and functional abnormalities were reported in the brain of patients with adolescent-onset schizophrenia (AOS). However, evidence of abnormal functional connectivity of the brain in AOS patients is limited. Thus, we analyzed the resting-state functional magnetic resonance scans of 48 drug-...
| Publicado en: | European Child & Adolescent Psychiatry Vol. 26; no. 7; pp. 839 - 846 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123821129&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123821129 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10188827 EJ3 jtl: European Child & Adolescent Psychiatry issn: 10188827 maglogo: N pubinfo: dt: Jul2017 vid: 26 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123821129 123821129 144067353 123821129 10.1007/s00787-017-0958-2 123821129 ppf: 839 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Abnormal functional connectivity strength in patients with adolescent-onset schizophrenia: a resting-state fMRI study. aug: au: Wang, Shuai Zhan, Yajing Zhang, Yan Lv, Luxian Wu, Renrong Zhao, Jingping Guo, Wenbin affil: Hunan Key Laboratory of Psychiatry and Mental Health , Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center On Mental Health Disorders, National Technology Institute On Mental Disorders , No. 139, Middle Renming Road Changsha 410011 People's Republic of China sug: subj: Adolescent Health Schizophrenia Brain Physiology Human Magnetic Resonance Imaging Adolescence Adolescent: 13-18 years ab: Structural and functional abnormalities were reported in the brain of patients with adolescent-onset schizophrenia (AOS). However, evidence of abnormal functional connectivity of the brain in AOS patients is limited. Thus, we analyzed the resting-state functional magnetic resonance scans of 48 drug-naive AOS patients and 31 healthy controls to determine their functional connectivity strength (FCS) and examined if FCS abnormalities were correlated with clinical characteristics. Compared with healthy controls, AOS patients showed significantly increased FCS in the left cerebellum VI and right inferior frontal gyrus/insula. A positive correlation was observed between FCS values in the right inferior frontal gyrus/insula and general psychopathology scores of positive and negative syndrome scale. Results suggest that functional connectivity pattern is disrupted in drug-naive AOS patients. The FCS values in this abnormal region have potential for evaluating the disease severity. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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