Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume.
Objectives: To evaluate the added value of amide proton transfer (APT) imaging to the apparent diffusion coefficient (ADC) from diffusion tensor imaging (DTI) and the relative cerebral blood volume (rCBV) from perfusion magnetic resonance imaging (MRI) for discriminating between high- and low-grade...
| Publicado en: | European Radiology Vol. 27; no. 8; pp. 3181 - 3190 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123837835&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123837835 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2017 vid: 27 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123837835 123837835 144106085 NLM28116517 10.1007/s00330-017-4732-0 NLM28116517 123837835 ppf: 3181 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Amide proton transfer imaging to discriminate between low- and high-grade gliomas: added value to apparent diffusion coefficient and relative cerebral blood volume. aug: au: Choi, Yoon Ahn, Sung Lee, Seung-Koo Chang, Jong Kang, Seok-Gu Kim, Se Zhou, Jinyuan Choi, Yoon Seong Ahn, Sung Soo Chang, Jong Hee Kim, Se Hoon affil: Department of Radiology and Research Institute of Radiological Science, College of Medicine , Yonsei University College of Medicine , 50 Yonsei-ro, Seodaemun-gu Seoul 120-752 Korea sug: subj: Magnetic Resonance Imaging Brain Neoplasms Magnetic Resonance Imaging Methods Glioma Sensitivity and Specificity Male Brain Neoplasms Pathology Neuroradiography Methods Neoplasm Grading Methods Amides Aged Middle Age ROC Curve Glioma Pathology Protons Adult Female Aged: 65+ years Middle Aged: 45-64 years Adult: 19-44 years Male Female ab: Objectives: To evaluate the added value of amide proton transfer (APT) imaging to the apparent diffusion coefficient (ADC) from diffusion tensor imaging (DTI) and the relative cerebral blood volume (rCBV) from perfusion magnetic resonance imaging (MRI) for discriminating between high- and low-grade gliomas.Methods: Forty-six consecutive adult patients with diffuse gliomas who underwent preoperative APT imaging, DTI and perfusion MRI were enrolled. APT signals were compared according to the World Health Organization grade. The diagnostic ability and added value of the APT signal to the ADC and rCBV for discriminating between low- and high-grade gliomas were evaluated using receiver operating characteristic (ROC) analyses and integrated discrimination improvement.Results: The APT signal increased as the glioma grade increased. The discrimination abilities of the APT, ADC and rCBV values were not significantly different. Using both the APT signal and ADC significantly improved discrimination vs. the ADC alone (area under the ROC curve [AUC], 0.888 vs. 0.910; P = 0.007), whereas using both the APT signal and rCBV did not improve discrimination vs. the rCBV alone (AUC, 0.927 vs. 0.923; P = 0.222).Conclusions: APT imaging may be a useful imaging biomarker that adds value to the ADC for discriminating between low- and high-grade gliomas.Key Points: • Higher APT values were correlated with higher glioma grades. • Adding the APT signal to the ADC improved glioma grading. • Adding the APT signal to rCBV did not improve glioma grading. • APT is a useful adjunct to the ADC for glioma grading. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|