Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma.
Objectives: Vascular characteristics of tumour and peritumoral volumes of high-grade gliomas change with treatment. This work evaluates the variations of T2*-weighted perfusion parameters as overall survival (OS) predictors.Methods: Forty-five patients with histologically confirmed high-grade astroc...
| Published in: | European Radiology Vol. 27; no. 8; pp. 3392 - 3401 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Aug2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123837861&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123837861 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Aug2017 vid: 27 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123837861 123837861 144069076 NLM27999986 10.1007/s00330-016-4699-2 NLM27999986 123837861 ppf: 3392 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma. aug: au: Sanz-Requena, Roberto Revert-Ventura, Antonio García-Martí, Gracián Salamé-Gamarra, Fares Pérez-Girbés, Alexandre Mollá-Olmos, Enrique Martí-Bonmatí, Luis Revert-Ventura, Antonio J affil: Radiology Department , Hospital de Manises , Av Generalitat Valenciana 50 46940 Manises Spain sug: subj: Brain Neoplasms Neovascularization, Pathologic Glioma Combined Modality Therapy Glioma Blood Supply Female Aged Brain Neoplasms Blood Supply Prognosis Magnetic Resonance Imaging Methods Glioma Therapy Male Brain Neoplasms Pathology Brain Neoplasms Therapy Perfusion Glioma Pathology Retrospective Design Kaplan-Meier Estimator Cerebrovascular Circulation Neoplasm Grading Adult Middle Age Scales Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objectives: Vascular characteristics of tumour and peritumoral volumes of high-grade gliomas change with treatment. This work evaluates the variations of T2*-weighted perfusion parameters as overall survival (OS) predictors.Methods: Forty-five patients with histologically confirmed high-grade astrocytoma (8 grade III and 37 grade IV) were included. All patients underwent pre- and post-treatment T2*-weighted contrast-enhanced magnetic resonance (MR) imaging. Tumour, peritumoral and control volumes were segmented. Relative variations of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), Ktrans-T2*, kep-T2*, ve-T2* and vp-T2* were calculated. Differences regarding tumour grade and surgical resection extension were evaluated with ANOVA tests. For each parameter, two groups were defined by non-supervised clusterisation. Survival analysis were performed on these groups.Results: For the tumour region, the 90th percentile increase or stagnation of CBV was associated with shorter survival, while a decrease related to longer survival (393 ± 189 vs 594 ± 294 days; log-rank p = 0.019; Cox hazard-ratio, 2.31; 95% confidence interval [CI], 1.12-4.74). Ktrans-T2* showed similar results (414 ± 177 vs 553 ± 312 days; log-rank p = 0.037; hazard-ratio, 2.19; 95% CI, 1.03-4.65). The peritumoral area values showed no relationship with OS.Conclusions: Post-treatment variations of the highest CBV and Ktrans-T2* values in the tumour volume are predictive factors of OS in patients with high-grade gliomas.Key Points: • Vascular characteristics of high-grade glioma tumour and peritumoral regions change with treatment. • Quantitative assessment of MRI perfusion provides valuable information regarding tumour aggressiveness. • Quantitative T2*-weighted perfusion parameters can help to predict overall survival. • Post-treatment variations of CBV and K trans-T2 values are predictive factors of OS. • Increased values may justify treatment intensification in these patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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