Microstructure changes of occipital white matter are responsible for visual problems in the 3-4-year-old very low birth weight children.
Purpose: The main aim of the study was to evaluate which factors affect the long-time visual function in preterm children, whether it is prematurity or retinopathy of prematurity or perhaps disturbances in the visual pathway.Materials and Methods: Fifty-eight children with mean birth weight 1016 g (...
| Publicado en: | Indian Journal of Ophthalmology Vol. 65; no. 6; pp. 493 - 500 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wolters Kluwer India Pvt Ltd
Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123861963&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123861963 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03014738 1BRZ jtl: Indian Journal of Ophthalmology issn: 03014738 maglogo: N pubinfo: dt: Jun2017 vid: 65 iid: 6 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 123861963 123861963 NLM28643715 123861963 10.4103/ijo.IJO_679_16 NLM28643715 123861963 ppf: 493 ppct: 7 formats: tig: atl: Microstructure changes of occipital white matter are responsible for visual problems in the 3-4-year-old very low birth weight children. aug: au: Lesniak, Anna Herman-Sucharska, Izabela Klimek, Małgorzata Karcz, Paulina Kubatko-Zielińska, Anna Nitecka, Magdalena Dutkowska, Grażyna Romanowska-Dixon, Bożena Kwinta, Przemko affil: Department of Ophthalmology and Ocular Oncology, Jagiellonian University Medical College, Kopernika 25, Cracow, Poland sug: subj: Infant, Premature Vision Disorders Diagnosis Brain Magnetic Resonance Imaging Methods Infant, Very Low Birth Weight Neural Pathways Evoked Potentials, Visual Physiology Prospective Studies Female Brain Physiopathology Neural Pathways Physiopathology Vision Disorders Physiopathology Male Visual Perception Child, Preschool Human Child, Preschool: 2-5 years Female Male ab: Purpose: The main aim of the study was to evaluate which factors affect the long-time visual function in preterm children, whether it is prematurity or retinopathy of prematurity or perhaps disturbances in the visual pathway.Materials and Methods: Fifty-eight children with mean birth weight 1016 g (range 520-1500 g) were evaluated at mean age 48 months (range 42-54 months). All children underwent magnetic resonance imaging (MRI) studies, visual evoked potentials (VEPs), and the Developmental Test of Visual Perception (DTVP). The MRI evaluation included diffusion tensor imaging and fractional anisotropy (FA), and colored orientation maps were calculated for each subject. Based on the results of the VEP evaluation, children were divided into two groups: A-abnormal results of VEP (n = 16) and B-normal VEP results (comparison group, n = 42).Results: FA values of inferior left and right occipital white matter (OWM) were lower in the group of children with abnormal VEP compared to the comparison group (0.34 ± 0.06 vs. 0.38 ± 0.06; P = 0.047; 0.31 ± 0.04 vs. 0.36 ± 0.06; P = 0.007, respectively). Furthermore, there were correlations between the latency (r = -0.35; P = 0.01) and amplitude (r = 0.31; P = 0.02) and FA in OWM. Children with abnormal VEP had lower DTVP scores as compared with children with normal VEP results (88 ± 18 vs. 95 ± 16 points, P = 0.048). Finally, a multivariate logistic regression revealed that FA of the inferior OWM was the only independent risk factor for the abnormal VEP (P = 0.04).Conclusion: Visual perception, VEPs, and white matter microstructural abnormalities in very low birth weight children at the age of 3-4 are significantly correlated. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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