Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: A randomized double-blind placebo-controlled clinical trial.
Ethnopharmacological evidence Mentha pulegium L. leaves are used in the Iranian traditional medicine for the treatment of functional dyspepsia. Aim of study: To study the efficacy and safety of M. pulegium in the treatment of functional dyspepsia patients fulfilling the Rome III criteria. Materials...
| Publicado en: | Journal of Ethnopharmacology Vol. 206; pp. 267 - 274 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Elsevier B.V.
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123866633&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123866633 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03788741 3MS jtl: Journal of Ethnopharmacology issn: 03788741 maglogo: N pubinfo: dt: Jul2017 vid: 206 pid: 1004 pub: Elsevier B.V. artinfo: ui: 123866633 123866633 123866633 10.1016/j.jep.2017.05.026 123866633 ppf: 267 ppct: 7 formats: tig: atl: Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. aug: au: Khonche, Ahmad Fallah Huseini, Hasan abdi, Hamed Mohtashami, Reza Nabati, Farzaneh Kianbakht, Saeed affil: Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran sug: subj: Dyspepsia Drug Therapy Medicine, Traditional Iran Clinical Effectiveness Plants, Medicinal Iran Human Iran Plant Extracts Clinical Assessment Tools P-Value ab: Ethnopharmacological evidence Mentha pulegium L. leaves are used in the Iranian traditional medicine for the treatment of functional dyspepsia. Aim of study: To study the efficacy and safety of M. pulegium in the treatment of functional dyspepsia patients fulfilling the Rome III criteria. Materials and methods The efficacy and safety of a standardized Mentha pulegium leaf extract (drug extract ratio: 15.9:1, extraction solvent: 70% v/v aqueous ethanol) (330 mg three times daily taken for 2 months) as add-on to one famotidine 40 mg tablet per day in the treatment of 50 functional dyspepsia patients were compared with those of a parallel placebo group (n =50). Results The extract significantly decreased the total dyspepsia score measured by the Hong Kong dyspepsia index compared to the placebo and baseline ( P =0.011 and P <0.001 respectively). The stomach pain, upper abdominal bloating, upper abdominal dull ache, belching and total dyspepsia scores were decreased from baseline in the extract group significantly compared to the placebo ( P <0.001, P <0.001, P =0.003, P <0.001 and P <0.001 respectively). However, the decreases of other dyspepsia symptoms scores from baseline in the extract group were not significant compared to the placebo ( P >0.05). The extract improved the quality of life measured by the SF-36 questionnaire significantly compared to the placebo and baseline ( P =0.003 and P <0.001 respectively). Moreover, the extract lowered the rate of H. pylori infection determined by the urease test significantly compared to the placebo and baseline ( P =0.001 and P <0.001 respectively). The extract did not significantly affect the complete blood count and liver and kidney function tests ( P >0.05). The patients did not experience any adverse drug effect. Conclusions M. pulegium extract (genuine drug extract ratio: 19.4:1; extraction solvent: 70% v/v aqueous ethanol) 270 mg three times daily taken for 2 months as adjunct to one famotidine 40 mg tablet per day seems safe, improves dyspeptic symptoms and quality of life and eradicates H. pylori in functional dyspepsia patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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