A one-step immune-chromatographic Helicobacter pylori stool antigen test for children was quick, consistent, reliable and specific.
Aim: This French study assessed a quick, noninvasive, immuno-chromatographic, Helicobacter pylori (H. pylori) stool antigen test for detecting infections in children.Methods: We enrolled 158 children, with a median age of 8.5 years (range eight months to 17 years), with digestive symptoms suggesting...
| Publicado en: | Acta Paediatrica Vol. 106; no. 7 |
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| Autores principales: | , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123872357&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123872357 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08035253 44C jtl: Acta Paediatrica issn: 08035253 maglogo: Y pubinfo: dt: Jul2017 vid: 106 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 123872357 123872357 NLM28667775 123872357 10.1111/apa.13968 NLM28667775 123872357 ppct: 1 formats: tig: atl: A one-step immune-chromatographic Helicobacter pylori stool antigen test for children was quick, consistent, reliable and specific. aug: au: Kalach, Nicolas Gosset, Pierre Dehecq, Eric Decoster, Anne Georgel, Anne-France Spyckerelle, Claire Papadopoulos, Stephanos Dupont, Christophe Raymond, Josette affil: Clinique Pédiatrique St Antoine, Hôpital St Vincent de Paul, Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), France sug: subj: Helicobacter Infections Diagnosis Feces Helicobacter Pylori Helicobacter Pylori Immunology Antigens, Bacterial Analysis Helicobacter Infections Microbiology Male Reproducibility of Results Female Helicobacter Infections Immunology Time Factors Child, Preschool Sensitivity and Specificity Infant Adolescence Child Human Child, Preschool: 2-5 years Infant: 1-23 months Adolescent: 13-18 years Child: 6-12 years Male Female ab: Aim: This French study assessed a quick, noninvasive, immuno-chromatographic, Helicobacter pylori (H. pylori) stool antigen test for detecting infections in children.Methods: We enrolled 158 children, with a median age of 8.5 years (range eight months to 17 years), with digestive symptoms suggesting upper gastrointestinal tract disease. Upper digestive endoscopy was performed with gastric biopsy specimens for histology, a rapid urease test, culture test and quantitative real-time polymerase chain reaction. The H. pylori stool antigen test was performed twice for each child and the results were compared to the reference method.Results: The reference methods showed that 23 (14.6%) of the 158 children tested were H. pylori positive. The H. pylori stool antigen test showed 91.3% sensitivity, with a 95% confidence interval (95% CI) of 86.9-95.6 and 97% specificity (95% CI 94.3-99.6), 30.84 positive likelihood ratio and 0.09 negative likelihood ratio. The test accuracy was 96.2% (95% CI 93.2-99.1). The two blinded independent observers produced identical H. pylori stool antigen test results and the Kappa coefficient for the H. pylori stool antigen test was one.Conclusion: The H. pylori stool antigen test was found to be a consistent, reliable, quick and specific test for detecting the H. pylori infection in children. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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