Abnormal baseline brain activity in Alzheimer's disease patients with depression: a resting-state functional magnetic resonance imaging study.
Purpose: As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clini...
| Publicado en: | Neuroradiology Vol. 59; no. 7; pp. 709 - 715 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123905142&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123905142 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Jul2017 vid: 59 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123905142 123905142 143978058 123905142 10.1007/s00234-017-1854-7 123905142 ppf: 709 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Abnormal baseline brain activity in Alzheimer's disease patients with depression: a resting-state functional magnetic resonance imaging study. aug: au: Liu, Xiaozheng Guo, Zhongwei Ding, Yanping Li, Jiapeng Wang, Gang Hou, Hongtao Chen, Xingli Yu, Enyan affil: China-USA Neuroimaging Research Institute, Department of Radiology of the Second Affiliated Hospital and Yuying Children's Hospital , Wenzhou Medical University , Wenzhou 325027 China sug: subj: Alzheimer's Disease Physiopathology Magnetic Resonance Imaging Methods Depression Brain Physiopathology Human Thalamus Pathology ab: Purpose: As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood. Methods: The current study sought to investigate low-frequency oscillations at the voxel level in D-AD patients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging. We examined 22 D-AD patients and 21 non-depressed AD (nD-AD) patients. Results: The results revealed that D-AD patients exhibited increased ALFF values in the left caudate and thalamus and decreased ALFF values in the left middle temporal pole compared with nD-AD patients. Conclusion: These findings may provide further insight into the underlying neuropathophysiology of AD with depression. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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