Quantitative Assessment of Airway Pathology in Subjects With COPD Using Low-Dose High-Resolution Computed Tomography.
BACKGROUND: The purpose of this study was to correlate airway parameters of COPD determined by low-dose high-resolution computed tomography (HRCT) with pulmonary function testing (PFT) results. METHODS: PFT data were collected for subjects with COPD and healthy controls. All subjects received inspir...
| Publicado en: | Respiratory Care Vol. 62; no. 7; pp. 953 - 963 |
|---|---|
| Autores principales: | , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jul2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123919101&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123919101 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Jul2017 vid: 62 iid: 7 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 123919101 123919101 123919101 10.4187/respcare.05186 123919101 ppf: 953 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Quantitative Assessment of Airway Pathology in Subjects With COPD Using Low-Dose High-Resolution Computed Tomography. aug: au: Huai Chen Gai-qun Chen Qing-si Zeng Ting-ting Xia Jia-xuan Zhou Shi-jun Qiu affil: Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China sug: subj: Pulmonary Disease, Chronic Obstructive Pathology Respiratory System Pathology Tomography, X-Ray Computed Methods Human Descriptive Statistics P-Value Respiratory Function Tests Respiration Bronchi Pulmonary Disease, Chronic Obstructive Classification Total Lung Capacity Forced Expiratory Volume Academic Medical Centers China Data Analysis Software Vital Capacity Kruskal-Wallis Test Mann-Whitney U Test Chi Square Test Two-Way Analysis of Variance Post Hoc Analysis Male Female Aged Middle Age Funding Source Aged: 65+ years Middle Aged: 45-64 years Male Female ab: BACKGROUND: The purpose of this study was to correlate airway parameters of COPD determined by low-dose high-resolution computed tomography (HRCT) with pulmonary function testing (PFT) results. METHODS: PFT data were collected for subjects with COPD and healthy controls. All subjects received inspiratory and expiratory phase low-dose HRCT. Bronchi in the apical segment of the right upper lobe (RB1), posterior segment of the right lower lobe (RB6), and lower lingual segment of the left upper lobe (LB5) were the target bronchi. Software automatically calculated airway wall area, inner area, and airway wall area percentage (percentage wall area for bronchial external area). RESULTS: A total of 75 COPD and 20 control subjects were included. The subjects with COPD were classified according to COPD stage, with 20 grade I, II, and III subjects, respectively, and 15 grade IV subjects. In COPD grade II, residual volume/total lung capacity was negatively correlated with airway wall area in LB5 (r = -0.51). In COPD grade III, FVC was negatively correlated with airway wall area percentage in LB5 (r = -0.49) but positively correlated with airway wall area in RB6 (r = 0.52); percent-of-predicted FEV1 was negatively correlated with airway wall area percentage in RB1 (r = -0.49); residual volume was negatively correlated with airway wall area (r = -0.47), and total lung capacity was negatively correlated with airway wall area in RB1 (r = -0.52) (all, P < .001). CONCLUSIONS: The results of this study suggest that airway parameters in different COPD grades have no uniform tendency of correlation with PFT, but some HRCT parameters are correlated to some PFT parameters. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|