Advancing Immunotherapy in Metastatic Breast Cancer.
Opinion Statement: Despite many advances in the treatment of breast cancer, the development of metastatic disease remains an incurable and frequent cause of cancer death for women worldwide. An improved understanding of the role of host immunosurveillance in modulating breast cancer disease biology,...
| Publicado en: | Current Treatment Options in Oncology Vol. 18; no. 6; pp. 1 - 16 |
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| Autores principales: | , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
Jun2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=123991955&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 123991955 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15272729 3KHC jtl: Current Treatment Options in Oncology issn: 15272729 maglogo: N pubinfo: dt: Jun2017 vid: 18 iid: 6 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 123991955 123991955 NLM28534250 123991955 10.1007/s11864-017-0478-9 NLM28534250 123991955 ppf: 1 ppct: 15 formats: fmt: @attributes: type: P tig: atl: Advancing Immunotherapy in Metastatic Breast Cancer. aug: au: Mansour, Mariam Teo, Zhi Luen, Stephen Loi, Sherene Teo, Zhi Ling Luen, Stephen J affil: Division of Research, Peter MacCallum Cancer Centre , University of Melbourne , 305 Grattan St Melbourne 3000 Australia sug: subj: Breast Neoplasms Immunology Breast Neoplasms Therapy Immunotherapy Methods Immunotherapy Adverse Effects Drug Therapy Neoplasm Staging Lymphocytes Drug Effects Immunity, Cellular Immune System Physiology Antineoplastic Agents Pharmacodynamics Neoplasm Metastasis Antibodies, Monoclonal Pharmacodynamics Cell Physiology Immunology Antineoplastic Agents Therapeutic Use Signal Transduction Drug Effects Disease Management Lymphocyte Subsets Immunology Lymphocytes Immunology Patient Selection Lymphocyte Subsets Drug Effects Prognosis Lymphocytes Metabolism Cell Physiology Antibodies, Monoclonal Therapeutic Use Cell Physiology Drug Effects Lymphocyte Subsets Metabolism Breast Neoplasms Metabolism Breast Neoplasms Diagnosis Female Female ab: Opinion Statement: Despite many advances in the treatment of breast cancer, the development of metastatic disease remains an incurable and frequent cause of cancer death for women worldwide. An improved understanding of the role of host immunosurveillance in modulating breast cancer disease biology, as well as impressive survival benefits seen to checkpoint blockade in other malignancies have provided great hope for an expanding role of immunotherapies in breast cancer management. While these novel therapies are currently being investigated in clinical trials, signals of efficacy, and tolerability in early phase studies suggest these will eventually make their way into standard practice algorithms. Ongoing research has highlighted a high degree of intertumoural heterogeneity in tumour lymphocytic infiltrates, suggesting some tumours or subtypes are more immunogenic than others. Furthermore, tumour intrinsic mechanisms of immune evasion are beginning to be uncovered, potentially representing key therapeutic targets to use in combination with checkpoint blockade, exemplifying the emerging concept of personalised medicine approaches to immune therapies. Subsequently, different immunotherapeutic strategies may be required based on stratification by these factors-for the minority of tumours with a high level of pre-existing immunity, immune checkpoint blockade monotherapy may be sufficient. However, for the majority of tumours with lower levels of pre-existing immunity, combination approaches will likely be required to achieve maximal therapeutic effect. Results of ongoing clinical trials including combinations with chemotherapy, radiation therapy, and targeted therapies are eagerly awaited. pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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