Single-scan rest/stress imaging: validation in a porcine model with F-Flurpiridaz.
Purpose: F-labeled myocardial flow agents are becoming available for clinical application but the ∼2 hour half-life of F complicates their clinical application for rest-stress measurements. The goal of this work is to evaluate in a pig model a single-scan method which provides quantitative rest-stre...
| Publicado en: | European Journal of Nuclear Medicine & Molecular Imaging Vol. 44; no. 9; pp. 1538 - 1547 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124071054&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124071054 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16197070 NPC jtl: European Journal of Nuclear Medicine & Molecular Imaging issn: 16197070 maglogo: N pubinfo: dt: Aug2017 vid: 44 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124071054 144013383 10.1007/s00259-017-3684-6 124071054 ppf: 1538 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Single-scan rest/stress imaging: validation in a porcine model with F-Flurpiridaz. aug: au: Ptaszek, Leon Guehl, Nicolas Normandin, Marc Wooten, Dustin Sitek, Arkadiusk Shoup, Timothy Fakhri, Georges Alpert, Nathaniel Rozen, Guy Ruskin, Jeremy affil: Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital , Harvard Medical School , Boston USA sug: ab: Purpose: F-labeled myocardial flow agents are becoming available for clinical application but the ∼2 hour half-life of F complicates their clinical application for rest-stress measurements. The goal of this work is to evaluate in a pig model a single-scan method which provides quantitative rest-stress blood flow in less than 15 minutes. Methods: Single-scan rest-stress measurements were made using F-Flurpiridaz. Nine scans were performed in healthy pigs and seven scans were performed in injured pigs. A two-injection, single-scan protocol was used in which an adenosine infusion was started 4 minutes after the first injection of F-Flurpiridaz and followed either 3 or 6 minutes later by a second radiotracer injection. In two pigs, microsphere flow measurements were made at rest and during stress. Dynamic images were reoriented into the short axis view, and regions of interest (ROIs) for the 17 myocardial segments were defined in bull's eye fashion. PET data were fitted with MGH2, a kinetic model with time varying kinetic parameters, in which blood flow changes abruptly with the introduction of adenosine. Rest and stress myocardial blood flow (MBF) were estimated simultaneously. Results: The first 12-14 minutes of rest-stress PET data were fitted in detail by the MGH2 model, yielding MBF measurement with a mean precision of 0.035 ml/min/cc. Mean myocardial blood flow across pigs was 0.61 ± 0.11 mL/min/cc at rest and 1.06 ± 0.19 mL/min/cc at stress in healthy pigs and 0.36 ± 0.20 mL/min/cc at rest and 0.62 ± 0.24 mL/min/cc at stress in the ischemic area. Good agreement was obtained with microsphere flow measurement (slope = 1.061 ± 0.017, intercept = 0.051 ± 0.017, mean difference 0.096 ± 0.18 ml/min/cc). Conclusion: Accurate rest and stress blood flow estimation can be obtained in less than 15 min of PET acquisition. The method is practical and easy to implement suggesting the possibility of clinical translation. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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