Analysis of Total and Transferrin-Bound Iron from Serum Samples: Incorporating structural constraints into pharmacokinetic studies of iron sucrose formulations.
Results from assays conducted independently of one another can produce findings that are incompatible with underlying physiologic constraints as a result of random errors. The authors investigate one such instance here, relating to assays of total iron and transferrin-bound iron concentrations in se...
| Publicado en: | Pharmaceutical Technology Europe Vol. 29; no. 7; pp. 28 - 32 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
MJH Life Sciences
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | Results from assays conducted independently of one another can produce findings that are incompatible with underlying physiologic constraints as a result of random errors. The authors investigate one such instance here, relating to assays of total iron and transferrin-bound iron concentrations in sera. A method of adjusting the observed total and transferrin-bound iron concentrations in these settings was outlined. The key of this approach was to satisfy the intrinsic physiologic constraint that the total serum concentration of iron is at least as great as the serum concentration of transferrin-bound iron. The adjustment method proposed by the authors can be readily applied in other settings that have physiologic constraints. |
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