Texture analysis of the liver at MDCT for assessing hepatic fibrosis.
Purpose: To evaluate CT texture analysis (CTTA) for staging of hepatic fibrosis (stages F0-F4) Methods: Quantitative texture analysis (QTA) of the liver was performed on abdominal MDCT scans using commercially available software (TexRAD), which uses a filtration-histogram statistic-based technique....
| Publicado en: | Abdominal Radiology Vol. 42; no. 8; pp. 2069 - 2079 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124202651&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124202651 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Aug2017 vid: 42 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124202651 144122733 10.1007/s00261-017-1096-5 124202651 ppf: 2069 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Texture analysis of the liver at MDCT for assessing hepatic fibrosis. aug: au: Lubner, Meghan Malecki, Kyle Kloke, John Ganeshan, Balaji Pickhardt, Perry affil: Department of Radiology, School of Medicine and Public Health , University of Wisconsin , E3/311 Clinical Science Center, 600 Highland Ave. Madison 53792-3252 USA sug: ab: Purpose: To evaluate CT texture analysis (CTTA) for staging of hepatic fibrosis (stages F0-F4) Methods: Quantitative texture analysis (QTA) of the liver was performed on abdominal MDCT scans using commercially available software (TexRAD), which uses a filtration-histogram statistic-based technique. Single-slice ROI measurements of the total liver, Couinaud segments IV-VIII, and segments I-III were obtained. CTTA parameters were correlated against fibrosis stage (F0-F4), with biopsy performed within one year for all cases with intermediate fibrosis (F1-F3). Results: The study cohort consisted of 289 adults (158M/131W; mean age, 51 years), including healthy controls (F0, n = 77), and patients with increasing stages of fibrosis (F1, n = 42; F2 n = 37; F3 n = 53; F4 n = 80). Mean gray-level intensity increased with fibrosis stage, demonstrating an ROC AUC of 0.78 at medium filtration for F0 vs F1-4, with sensitivity and specificity of 74% and 74% at cutoff 0.18. For significant fibrosis (≥F2), mean showed AUCs ranging from 0.71-0.73 across medium- and coarse- filtered textures with sensitivity and specificity of 71% and 68% at cutoff of 0.3, with similar performance also observed for advanced fibrosis (≥F3). Entropy showed a similar trend. Conversely, kurtosis and skewness decreased with increasing fibrosis, particularly in cirrhotic patients. For cirrhosis (≥F4), kurtosis and skewness showed AUCs of 0.86 and 0.87, respectively, at coarse-filtered scale, with skewness showing a sensitivity and specificity of 84% and 75% at cutoff of 1.3. Conclusion: CTTA may be helpful in detecting the presence of hepatic fibrosis and discriminating between stages of fibrosis, particularly at advanced levels. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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