Caffeine increases the velocity of rapid eye movements in unfatigued humans.
Background: Caffeine is a widely used dietary stimulant that can reverse the effects of fatigue on cognitive, motor and oculomotor function. However, few studies have examined the effect of caffeine on the oculomotor system when homeostasis has not been disrupted by physical fatigue. This study exam...
| Publicado en: | Psychopharmacology Vol. 234; no. 15; pp. 2311 - 2324 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124215508&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124215508 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Aug2017 vid: 234 iid: 15 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124215508 143909348 10.1007/s00213-017-4638-1 124215508 ppf: 2311 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Caffeine increases the velocity of rapid eye movements in unfatigued humans. aug: au: Connell, Charlotte Thompson, Benjamin Turuwhenua, Jason Hess, Robert Gant, Nicholas affil: Department of Optometry and Vision Science , University of Auckland , Auckland New Zealand sug: ab: Background: Caffeine is a widely used dietary stimulant that can reverse the effects of fatigue on cognitive, motor and oculomotor function. However, few studies have examined the effect of caffeine on the oculomotor system when homeostasis has not been disrupted by physical fatigue. This study examined the influence of a moderate dose of caffeine on oculomotor control and visual perception in participants who were not fatigued. Methods: Within a placebo-controlled crossover design, 13 healthy adults ingested caffeine (5 mg·kg body mass) and were tested over 3 h. Eye movements, including saccades, smooth pursuit and optokinetic nystagmus, were measured using infrared oculography. Results: Caffeine was associated with higher peak saccade velocities (472 ± 60° s) compared to placebo (455 ± 62° s). Quick phases of optokinetic nystagmus were also significantly faster with caffeine, whereas pursuit eye movements were unchanged. Non-oculomotor perceptual tasks (global motion and global orientation processing) were unaffected by caffeine. Conclusions: These results show that oculomotor control is modulated by a moderate dose of caffeine in unfatigued humans. These effects are detectable in the kinematics of rapid eye movements, whereas pursuit eye movements and visual perception are unaffected. Oculomotor functions may be sensitive to changes in central catecholamines mediated via caffeine's action as an adenosine antagonist, even when participants are not fatigued. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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