F-18 FDG PET differentiation of benign from malignant chondroid neoplasms: a systematic review of the literature.
Introduction: Discriminating among benign chondroid tumors, low-grade chondrosarcomas, and grade 2/3 chondrosarcomas is frequently difficult with standard imaging modalities. We systematically reviewed the literature to determine the performance of PET-CT in making this distinction.Methods: A system...
| Publicado en: | Skeletal Radiology Vol. 46; no. 9; pp. 1233 - 1240 |
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| Autores principales: | , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124215770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124215770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Sep2017 vid: 46 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124215770 124215770 144156134 NLM28608242 124215770 10.1007/s00256-017-2685-7 NLM28608242 124215770 ppf: 1233 ppct: 7 formats: fmt: @attributes: type: P tig: atl: F-18 FDG PET differentiation of benign from malignant chondroid neoplasms: a systematic review of the literature. aug: au: Subhawong, Ty Winn, Aaron Shemesh, Shai Pretell-Mazzini, Juan Subhawong, Ty K Shemesh, Shai S affil: Department of Radiology , University of Miami Miller School of Medicine/Jackson Memorial Hospital , 1611 NW 12th Ave., JMH WW 279 Miami 33136 USA sug: subj: Chondrosarcoma Chondroma Chondroma Pathology Chondrosarcoma Pathology Human Neoplasm Grading Radiopharmaceuticals Fludeoxyglucose F 18 Diagnosis, Differential Systematic Review ab: Introduction: Discriminating among benign chondroid tumors, low-grade chondrosarcomas, and grade 2/3 chondrosarcomas is frequently difficult with standard imaging modalities. We systematically reviewed the literature to determine the performance of PET-CT in making this distinction.Methods: A systematic review was performed identifying 811 PubMed- and Embase-indexed articles containing combinations of "chondrosarcoma," "enchondroma," "chondroid," "cartilage" and "PET/CT," "PET," "positron." Eight articles including 166 lesions were included. Age, gender, tumor size, histologic grade, and SUVmax values were extracted for individual lesions when possible and otherwise recorded as aggregated data. Comparisons in SUVmax among benign, low-grade, and intermediate-/high-grade chondroid neoplasms were made.Results: Individual SUVs were available for 101 lesions; 65 additional lesions were reported as aggregated data. There were 101 malignant and 65 benign tumors. Benign tumors were seen more frequently in females (p = 0.04, Fischer's exact test), but malignancy was not associated with age or lesion size. SUVmax was lower for benign (1.6 ± 0.7) than malignant tumors (4.4 ± 2.5) (p < 0.0001, t-test). SUVmax was lower for grade 0/1 (2.0 ± 0.7) than grade 2/3 (6.0 ± 3.2) (p < 0.0001, t-test). Increasing SUVmax correlated with higher grade chondroid tumors (Spearman's rank, ρ = 0.78). SUVmax ≥4.4 was 99% specific for grade 2/3 chondrosarcoma.Conclusions: SUVmax correlates with histologic grade in intraosseous chondroid neoplasms; very low SUVmax supports a diagnosis of benign tumor, while elevated SUVmax is suggestive of higher grade chondrosarcoma. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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