Evaluation of Cholesterol as a Biomarker for Suicidality in a Veteran Sample.
A reduction in total cholesterol may alter the microviscosity of the brain-cell-membrane, reducing serotonin receptor exposure. The resulting imbalance between serotonin and dopamine may lead to an increased risk for suicidality. The objective of this research was to evaluate total cholesterol as a...
| Publicado en: | Research in Nursing & Health Vol. 40; no. 4; pp. 341 - 350 |
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| Autores principales: | , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124255915&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124255915 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01606891 1Y3 jtl: Research in Nursing & Health issn: 01606891 maglogo: Y pubinfo: dt: Aug2017 vid: 40 iid: 4 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 124255915 124255915 124255915 10.1002/nur.21794 124255915 ppf: 341 ppct: 9 formats: tig: atl: Evaluation of Cholesterol as a Biomarker for Suicidality in a Veteran Sample. aug: au: Reuter, Chuck Caldwell, Barbara Basehore, Heather affil: The City University of New York − Hunter Bellevue School of Nursing, 425 East 25th Street, Mailbox: 906, New York NY 10010 sug: subj: Veterans Psychosocial Factors Suicide Risk Factors Biological Markers Cholesterol Blood Human Hospitals, Veterans Pennsylvania Pennsylvania Record Review Electronic Health Records Convenience Sample Suicidal Ideation Suicide, Attempted Age Factors Anxiety Educational Status Neurotransmitters Serotonin Retrospective Design Descriptive Research Descriptive Statistics Power Analysis Male Female Adult Middle Age Aged Analysis of Variance Repeated Measures Hematologic Tests Confidence Intervals Chi Square Test Antilipemic Agents Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: A reduction in total cholesterol may alter the microviscosity of the brain-cell-membrane, reducing serotonin receptor exposure. The resulting imbalance between serotonin and dopamine may lead to an increased risk for suicidality. The objective of this research was to evaluate total cholesterol as a biological marker for suicidality in a sample of US military veterans. The study population consisted of veterans who received care at the Coatesville Veterans Affairs Medical Center (VAMC) and were included in the Suicide Prevention Coordinator's database for having suicidal ideation with evidence of escalating intent, a documented suicide attempt, or committed suicide between 2009 and 2015. The veterans' medical data were obtained from the facility's computerized patient record system. The final sample was 188 observations from 128 unique veterans. Veterans with total cholesterol levels below 168 mg/dl appeared to have a higher suicide risk than those with higher levels. The cholesterol levels of veterans reporting suicidal ideation or attempt were significantly lower than the group reporting neither [ F(2, 185) = 30.19, p < .001]. When data from multiple visits were available, veterans reporting suicidal ideation or attempt had experienced a significant (20%) decrease in cholesterol levels from an earlier visit in which they did not report suicidality. A latent class analysis revealed that among other differences, suicidal veterans were younger, leaner, and had more anxiety, sleep problems, and higher education than those being seen for an issue unrelated to suicidality. © 2017 Wiley Periodicals, Inc. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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