Corneal Alterations Associated with Pseudoexfoliation Syndrome and Glaucoma: A Literature Review.
A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and cornea...
| Publicado en: | Journal of Ophthalmic & Vision Research Vol. 12; no. 3; pp. 312 - 328 |
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| Autores principales: | , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Knowledge E DMCC
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124268775&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124268775 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20082010 AY5S jtl: Journal of Ophthalmic & Vision Research issn: 20082010 maglogo: N pubinfo: dt: Jul2017 vid: 12 iid: 3 pid: 35682 pub: Knowledge E DMCC artinfo: ui: 124268775 124268775 124268775 10.4103/jovr.jovr_28_17 124268775 ppf: 312 ppct: 16 formats: fmt: @attributes: type: P tig: atl: Corneal Alterations Associated with Pseudoexfoliation Syndrome and Glaucoma: A Literature Review. aug: au: Palko, Joel R. Qi, Owen Sheybani, Arsham affil: Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO, USA sug: subj: Intraocular Pressure Uvea Pathology Cornea Anatomy and Histology Corneal Transplantation Cochrane Library Control Group Eye Cell Count Syndrome Systematic Review Literature Review Nonexperimental Studies Study Design Prospective Studies Descriptive Statistics Sensitivity and Specificity Scales ab: A systematic literature review was performed evaluating articles examining the effects of pseudoexfoliation syndrome (PEX) and glaucoma (PEXG) on the cornea with a focus on the corneal endothelium. We searched for articles relevant to pseudoexfoliation syndrome, pseudoexfoliation glaucoma and corneal endothelial cell counts using Pubmed, Google Scholar Database, Web of Science and Cochrane Library databases published prior to September of 2016. We then screened the references of these retrieved papers and performed a Web of Science cited reference search. Corneal characteristics analyzed included central corneal thickness (CCT), corneal nerve density, endothelial cell density (ECD), polymegathism, and pleomorphism. These parameters were compared in the following populations: control, PEX, PEXG, and primary open angle glaucoma (POAG). Over 30 observational studies were reviewed. Most studies showed a statistically significant lower ECD in PEX and PEXG populations compared to controls. Overall, PEX eyes had a non-statistically significant trend of lower ECDs compared to PEXG eyes. No consistent trends were found when analyzing differences in CCT amongst control, PEX and PEXG groups. For the few studies that looked at corneal nerve characteristics, the control groups were found to have statistically significantly greater nerve densities than PEX eyes, which had significantly greater densities than PEXG eyes. ECD and corneal nerve densities may be potential metrics for risk-stratifying patients with PEX and PEXG. Our literature review provided further evidence of the significant negative influence PEX has on the cornea, worsening as patients convert to PEXG. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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