Differences in dynamic and static functional connectivity between young and elderly healthy adults.
Purpose: Brain connectivity is highly dynamic, but functional connectivity (FC) studies using resting-state functional magnetic resonance imaging (rs-fMRI) assume it to be static. This study assessed differences in dynamic FC between young healthy adults (YH) and elderly healthy adults (EH) compared...
| Publicado en: | Neuroradiology Vol. 59; no. 8; pp. 781 - 790 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124297399&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124297399 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2017 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124297399 124297399 144172847 124297399 10.1007/s00234-017-1875-2 124297399 ppf: 781 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Differences in dynamic and static functional connectivity between young and elderly healthy adults. aug: au: Park, Ji Jung, Seung Ryu, Kyeoung Oh, Joo Kim, Ho Choi, Choong-Gon Kim, Sang Shim, Woo affil: Department of Radiology and Research Institute of Radiology , University of Ulsan College of Medicine, Asan Medical Center , 86 Asanbyeongwon-Gil Songpa-Gu 138-736 South Korea sug: subj: Magnetic Resonance Imaging Brain Time Adult Pearson's Correlation Coefficient Data Analysis, Statistical Time Series T-Tests Quantitative Studies Data Analysis Aged Adult: 19-44 years Aged: 65+ years ab: Purpose: Brain connectivity is highly dynamic, but functional connectivity (FC) studies using resting-state functional magnetic resonance imaging (rs-fMRI) assume it to be static. This study assessed differences in dynamic FC between young healthy adults (YH) and elderly healthy adults (EH) compared to static FC. Methods: Using rs-fMRI data from 12 YH and 31 EH, FC was assessed in six functional regions (subcortical, auditory [AUD], sensorimotor [SM], visuospatial [VS], cognitive control [CC], and default mode network [DMN]). Static FC was calculated as Fisher's z-transformed correlation coefficient. The sliding time window correlation (window size 30 s, step size 3 s) was applied for dynamic FC, and the standard deviation across sliding windows was calculated. Differences in static and dynamic FC between EH and YH were calculated and compared by region. Results: EH showed decreased static FC in the subcortical, CC, and DMN regions (FDR corrected p = 0.0013; 74 regions), with no regions showing static FC higher than that in YH. EH showed increased dynamic FC in the subcortical, CC, and DMN regions, whereas decreased dynamic FC in CC and DMN regions ( p < 0.01). However, the regions showing differences between EH and YH did not overlap between static and dynamic FC. Conclusion: Dynamic FC exhibited differences from static FC in EH and YH, mainly in regions involved in cognitive control and the DMN. Altered dynamic FC demonstrated both qualitatively and quantitatively distinct patterns of transient brain activity and needs to be studied as an imaging biomarker in the aging process. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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