Subject-specific regional measures of water diffusion are associated with impairment in chronic spinal cord injury.
Purpose: We aimed to identify non-invasive imaging parameters that can serve as biomarkers for the integrity of the spinal cord, which is paramount to neurological function. Diffusion tensor imaging (DTI) indices are sensitive to axonal and myelin damage, and have strong potential to serve as such b...
| Published in: | Neuroradiology Vol. 59; no. 8; pp. 747 - 759 |
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| Main Authors: | , , , , , |
| Format: | diagnostic images research tables/charts Journal Article |
| Published: |
Springer Nature
Aug2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124297408&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124297408 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00283940 NYZ jtl: Neuroradiology issn: 00283940 maglogo: N pubinfo: dt: Aug2017 vid: 59 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124297408 124297408 143930081 124297408 10.1007/s00234-017-1860-9 124297408 ppf: 747 ppct: 12 formats: fmt: @attributes: type: P tig: atl: Subject-specific regional measures of water diffusion are associated with impairment in chronic spinal cord injury. aug: au: Choe, Ann Sadowsky, Cristina Smith, Seth van Zijl, Peter Pekar, James Belegu, Visar sug: subj: Spinal Cord Injuries Spinal Cord Veterans Organizations Umbilical Cord Cervical Cord Diffusion Weights and Measures Linear Regression Two-Way Analysis of Variance Data Analysis Regression Descriptive Statistics Clinical Trials Case Studies Record Review Prospective Studies Effect Size Post Hoc Analysis Sensitivity and Specificity Analysis of Variance Scales Reliability Surveys ab: Purpose: We aimed to identify non-invasive imaging parameters that can serve as biomarkers for the integrity of the spinal cord, which is paramount to neurological function. Diffusion tensor imaging (DTI) indices are sensitive to axonal and myelin damage, and have strong potential to serve as such biomarkers. However, averaging DTI indices over large regions of interest (ROIs), a common approach to analyzing the images of injured spinal cord, leads to loss of subject-specific information. We investigated if DTI-tractography-driven, subject-specific demarcation approach can yield measures that are more specific to impairment. Methods: In 18 individuals with chronic spinal cord injury (SCI), subject-specific demarcation of the injury region was performed using DTI tractography, which yielded three regions relative to injury (RRI; regions superior to, at, and below injury epicenter). DTI indices averaged over each RRI were correlated with measures of residual motor and sensory function, obtained using the International Standard of Neurological Classification for Spinal Cord Injury (ISNCSCI). Results: Total ISNCSCI score (ISNCSCI-tot; sum of ISNCSCI motor and sensory scores) was significantly ( p < 0.05) correlated with fractional anisotropy and axial and radial diffusivities. ISNCSCI-tot showed strongest correlation with indices measured from the region inferior to the injury epicenter (IRRI), the degree of which exceeded that of those measured from the entire cervical cord-suggesting contribution from Wallerian degeneration. Conclusion: DTI tractography-driven, subject-specific injury demarcation approach provided measures that were more specific to impairment. Notably, DTI indices obtained from the IRRI region showed the highest specificity to impairment, demonstrating their strong potential as biomarkers for the SCI severity. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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