The Big Vitamin D Mistake.
Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities' decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance...
| Publicado en: | Journal of Preventive Medicine & Public Health Vol. 50; no. 4; pp. 278 - 282 |
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| Autor principal: | |
| Formato: | Journal Article |
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Korean Society for Preventive Medicine
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124389613&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124389613 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19758375 5G2I jtl: Journal of Preventive Medicine & Public Health issn: 19758375 maglogo: N pubinfo: dt: Jul2017 vid: 50 iid: 4 pid: 42498 pub: Korean Society for Preventive Medicine place: , <Blank> artinfo: ui: 124389613 124389613 NLM28768407 10.3961/jpmph.16.111 NLM28768407 124389613 ppf: 278 ppct: 4 formats: tig: atl: The Big Vitamin D Mistake. aug: au: Papadimitriou, Dimitrios T. affil: Third Department of Pediatrics, Division of Pediatric Endocrinology, Attikon University Hospital, University of Athens School of Medicine, Athens, Greece sug: ab: Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities' decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality, demolishing the previously presumed U-shape curve of mortality associated with vitamin D levels. Since all-disease mortality is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L, we call public health authorities to consider designating as the RDA at least three-fourths of the levels proposed by the Endocrine Society Expert Committee as safe upper tolerable daily intake doses. This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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