Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats.
Rationale: Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment pers...
| Publicado en: | Psychopharmacology Vol. 234; no. 16; pp. 2431 - 2442 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Aug2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124395663&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124395663 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Aug2017 vid: 234 iid: 16 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124395663 144096471 10.1007/s00213-017-4632-7 124395663 ppf: 2431 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Role of the agranular insular cortex in contextual control over cocaine-seeking behavior in rats. aug: au: Arguello, Amy Wang, Rong Lyons, Carey Higginbotham, Jessica Hodges, Matthew Fuchs, Rita affil: Integrative Physiology and Neuroscience, College of Veterinary Medicine , Washington State University , Pullman 99164-7620 USA sug: ab: Rationale: Environmental stimulus control over drug relapse requires the retrieval of context-response-cocaine associations, maintained in long-term memory through active reconsolidation processes. Identifying the neural substrates of these phenomena is important from a drug addiction treatment perspective. Objectives: The present study evaluated whether the agranular insular cortex (AI) plays a role in drug context-induced cocaine-seeking behavior and cocaine memory reconsolidation. Methods: Rats were trained to lever press for cocaine infusions in a distinctive context, followed by extinction training in a different context. Rats in experiment 1 received bilateral microinfusions of vehicle or a GABA agonist cocktail (baclofen and muscimol (BM)) into the AI or the overlying somatosensory cortex (SSJ, anatomical control region) immediately before a test of drug-seeking behavior (i.e., non-reinforced lever presses) in the previously cocaine-paired context. The effects of these manipulations on locomotor activity were also assessed in a novel context. Rats in experiment 2 received vehicle or BM into the AI after a 15-min reexposure to the cocaine-paired context, intended to reactivate context-response-cocaine memories and initiate their reconsolidation. The effects of these manipulations on drug context-induced cocaine-seeking behavior were assessed 72 h later. Results: BM-induced pharmacological inactivation of the AI, but not the SSJ, attenuated drug context-induced reinstatement of cocaine-seeking behavior without altering locomotor activity. Conversely, AI inactivation after memory reactivation failed to impair subsequent drug-seeking behavior and thus cocaine memory reconsolidation. Conclusions: These findings suggest that the AI is a critical element of the neural circuitry that mediates contextual control over cocaine-seeking behavior. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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