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Enhanced Energy Localization in Hyperthermia Treatment Based on Hybrid Electromagnetic and Ultrasonic System: Proof of Concept with Numerical Simulations.

This paper proposes a hybrid hyperthermia treatment system, utilizing two noninvasive modalities for treating brain tumors. The proposed system depends on focusing electromagnetic (EM) and ultrasound (US) energies. The EM hyperthermia subsystem enhances energy localization by incorporating a multich...

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Published in:BioMed Research International Vol. 2017; pp. 1 - 19
Main Authors: Nizam-Uddin, N., Elshafiey, Ibrahim
Format: equations & formulas pictorial review tables/charts Journal Article
Published: Wiley-Blackwell 8/1/2017
Online Access:View this record in EBSCOhost
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        23146133
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      dt: 8/1/2017
      vid: 2017
      pid: 480
      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        124417105
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        10.1155/2017/5787484
        124417105
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        atl: Enhanced Energy Localization in Hyperthermia Treatment Based on Hybrid Electromagnetic and Ultrasonic System: Proof of Concept with Numerical Simulations.
      aug:
        au:
          Nizam-Uddin, N.
          Elshafiey, Ibrahim
        affil: Electrical Engineering Department, King Saud University, Riyadh, Saudi Arabia
      sug:
        subj:
          Hyperthermia, Induced
          Ultrasonic Therapy Methods
          Electromagnetics
          Simulations
          Human
          Brain Neoplasms Therapy
          Models, Statistical
      ab: This paper proposes a hybrid hyperthermia treatment system, utilizing two noninvasive modalities for treating brain tumors. The proposed system depends on focusing electromagnetic (EM) and ultrasound (US) energies. The EM hyperthermia subsystem enhances energy localization by incorporating a multichannel wideband setting and coherent-phased-array technique. A genetic algorithm based optimization tool is developed to enhance the specific absorption rate (SAR) distribution by reducing hotspots and maximizing energy deposition at tumor regions. The treatment performance is also enhanced by augmenting an ultrasonic subsystem to allow focused energy deposition into deep tumors. The therapeutic faculty of ultrasonic energy is assessed by examining the control of mechanical alignment of transducer array elements. A time reversal (TR) approach is then investigated to address challenges in energy focus in both subsystems. Simulation results of the synergetic effect of both modalities assuming a simplified model of human head phantom demonstrate the feasibility of the proposed hybrid technique as a noninvasive tool for thermal treatment of brain tumors.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        review
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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