Exposure to fentanyl-contaminated heroin and overdose risk among illicit opioid users in Rhode Island: A mixed methods study.

Background: Illicit fentanyl use has become wide spread in the US, causing high rates of overdose deaths among people who use drugs. This study describes patterns and perceptions of fentanyl exposure among opioid users in Rhode Island.Methods: A mixed methods study was conducted via questionnaire wi...

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Publicado en:International Journal of Drug Policy Vol. 46; pp. 136 - 146
Autores principales: Carroll, Jennifer J., Marshall, Brandon D.L., Rich, Josiah D., Green, Traci C.
Formato: research Journal Article
Publicado: Elsevier B.V. Aug2017
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Aug2017
      vid: 46
      pid: 467
      pub: Elsevier B.V.
      place: New York, New York
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        10.1016/j.drugpo.2017.05.023
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        atl: Exposure to fentanyl-contaminated heroin and overdose risk among illicit opioid users in Rhode Island: A mixed methods study.
      aug:
        au:
          Carroll, Jennifer J.
          Marshall, Brandon D.L.
          Rich, Josiah D.
          Green, Traci C.
        affil: The Warren Alpert School of Medicine of Brown University, 222 Richmond St., Providence, RI 02903, USA
      sug:
        subj:
          Heroin Poisoning
          Fentanyl Poisoning
          Substance Use Disorders Complications
          Overdose Epidemiology
          Adolescence
          Young Adult
          Street Drugs
          Adult
          Interviews
          Relative Risk
          Rhode Island
          Middle Age
          Prevalence
          Male
          Female
          Harm Reduction
          Drug Contamination
          Analgesics, Opioid Poisoning
          Funding Source
          Human
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Male
          Female
      ab: Background: Illicit fentanyl use has become wide spread in the US, causing high rates of overdose deaths among people who use drugs. This study describes patterns and perceptions of fentanyl exposure among opioid users in Rhode Island.Methods: A mixed methods study was conducted via questionnaire with a convenience sample of 149 individuals using illicit opioids or misusing prescription opioids in Rhode Island between January and November 2016. Of these, 121 knew of fentanyl and reported known or suspected exposure to fentanyl in the past year. Semi-structured interviews were conducted with the first 47 participants.Results: Study participants were predominantly male (64%) and white (61%). Demographic variables were similar across sample strata. Heroin was the most frequently reported drug of choice (72%). Self-reported exposure to illicit fentanyl in the past year was common (50.4%, n=61). In multivariate models, regular (at least weekly) heroin use was independently associated with known or suspected fentanyl exposure in the past year (adjusted prevalence ratio (APR)=4.07, 95% CI: 1.24-13.3, p=0.020). In interviews, users described fentanyl as unpleasant, potentially deadly, and to be avoided. Participants reporting fentanyl exposure routinely experienced or encountered non-fatal overdose. Heroin users reported limited ability to identify fentanyl in their drugs. Harm reduction strategies used to protect themselves from fentanyl exposure and overdose, included test hits, seeking prescription opioids in lieu of heroin, and seeking treatment with combination buprenorphine/naloxone. Participants were often unsuccessful in accessing structured treatment programs.Conclusion: Among illicit opioid users in Rhode Island, known or suspected fentanyl exposure is common, yet demand for fentanyl is low. Fentanyl-contaminated drugs are generating user interest in effective risk mitigation strategies, including treatment. Responses to the fentanyl epidemic should be informed by the perceptions and experiences of local users. The rapid scale-up of buprenorphine/naloxone provision may slow the rate of fentanyl-involved overdose deaths.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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