A novel representation of inter-site tumour heterogeneity from pre-treatment computed tomography textures classifies ovarian cancers by clinical outcome.
Purpose: To evaluate the associations between clinical outcomes and radiomics-derived inter-site spatial heterogeneity metrics across multiple metastatic lesions on CT in patients with high-grade serous ovarian cancer (HGSOC).Methods: IRB-approved retrospective study of 38 HGSOC patients. All sites...
| Publicado en: | European Radiology Vol. 27; no. 9; pp. 3991 - 4002 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124485401&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124485401 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2017 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124485401 124485401 144061783 NLM28289945 124485401 10.1007/s00330-017-4779-y NLM28289945 124485401 ppf: 3991 ppct: 11 formats: fmt: @attributes: type: P tig: atl: A novel representation of inter-site tumour heterogeneity from pre-treatment computed tomography textures classifies ovarian cancers by clinical outcome. aug: au: Vargas, Hebert Veeraraghavan, Harini Micco, Maura Nougaret, Stephanie Lakhman, Yulia Meier, Andreas Sosa, Ramon Soslow, Robert Levine, Douglas Weigelt, Britta Aghajanian, Carol Hricak, Hedvig Deasy, Joseph Snyder, Alexandra Sala, Evis Vargas, Hebert Alberto Meier, Andreas A Soslow, Robert A Levine, Douglas A affil: Department of Radiology , Memorial Sloan Kettering Cancer Center , 1275 York Avenue New York 10065 USA sug: subj: Ovarian Neoplasms Pathology Retrospective Design Gene Amplification Tomography, X-Ray Computed Methods Adult Nucleic Acid Amplification Techniques Female Treatment Outcomes Ovarian Neoplasms Ovarian Neoplasms Mortality Proteins Middle Age Aged Human Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Female ab: Purpose: To evaluate the associations between clinical outcomes and radiomics-derived inter-site spatial heterogeneity metrics across multiple metastatic lesions on CT in patients with high-grade serous ovarian cancer (HGSOC).Methods: IRB-approved retrospective study of 38 HGSOC patients. All sites of suspected HGSOC involvement on preoperative CT were manually segmented. Gray-level correlation matrix-based textures were computed from each tumour site, and grouped into five clusters using a Gaussian Mixture Model. Pairwise inter-site similarities were computed, generating an inter-site similarity matrix (ISM). Inter-site texture heterogeneity metrics were computed from the ISM and compared to clinical outcomes.Results: Of the 12 inter-site texture heterogeneity metrics evaluated, those capturing the differences in texture similarities across sites were associated with shorter overall survival (inter-site similarity entropy, similarity level cluster shade, and inter-site similarity level cluster prominence; p ≤ 0.05) and incomplete surgical resection (similarity level cluster shade, inter-site similarity level cluster prominence and inter-site cluster variance; p ≤ 0.05). Neither the total number of disease sites per patient nor the overall tumour volume per patient was associated with overall survival. Amplification of 19q12 involving cyclin E1 gene (CCNE1) predominantly occurred in patients with more heterogeneous inter-site textures.Conclusion: Quantitative metrics non-invasively capturing spatial inter-site heterogeneity may predict outcomes in patients with HGSOC.Key Points: • Calculating inter-site texture-based heterogeneity metrics was feasible • Metrics capturing texture similarities across HGSOC sites were associated with overall survival • Heterogeneity metrics were also associated with incomplete surgical resection of HGSOC. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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