Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images-a voxel-based whole brain analysis.
Objectives: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis.Methods: In this retrospective single-centre study, 217 patients with a clinically isolated synd...
| Publicado en: | European Radiology Vol. 27; no. 9; pp. 3687 - 3694 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124485402&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124485402 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2017 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124485402 124485402 144097120 NLM28289935 124485402 10.1007/s00330-017-4777-0 NLM28289935 124485402 ppf: 3687 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Repeated intravenous administration of gadobutrol does not lead to increased signal intensity on unenhanced T1-weighted images-a voxel-based whole brain analysis. aug: au: Langner, Soenke Kromrey, Marie-Luise Kuehn, Jens-Peter Grothe, Matthias Domin, Martin affil: Institute of Diagnostic Radiology and Neuroradiology , University Medicine Greifswald , Ferdinand-Sauerbruch-Straße 17475 Greifswald Germany sug: subj: Contrast Media Administration and Dosage Brain Diseases Magnetic Resonance Imaging Methods Organometallic Compounds Administration and Dosage Male Brain Aged Female Adult Gray Matter Administration, Intravenous Middle Age Retrospective Design Cerebellum Pathology Human Aged: 65+ years Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objectives: To identify a possible association between repeated intravenous administration of gadobutrol and increased signal intensity in the grey and white matter using voxel-based whole-brain analysis.Methods: In this retrospective single-centre study, 217 patients with a clinically isolated syndrome underwent baseline brain magnetic resonance imaging and at least one annual follow-up examination with intravenous administration of 0.1 mmol/kg body weight of gadobutrol. Using the "Diffeomorphic Anatomical Registration using Exponentiated Lie algebra" (DARTEL) normalisation process, tissue templates for grey matter (GM), white matter (WM), and cerebrospinal fluid (CSF) were calculated, as were GM-CSF and WM-CSF ratios. Voxel-based whole-brain analysis was used to calculate the signal intensity for each voxel in each data set. Paired t-test was applied to test differences to baseline MRI for significance.Results: Voxel-based whole-brain analysis demonstrated no significant changes in signal intensity of grey and white matter after up to five gadobutrol administrations. There was no significant change in GM-CSF and grey WM-CSF ratios.Conclusion: Voxel-based whole-brain analysis did not demonstrate increased signal intensity of GM and WM on unenhanced T1-weighted images after repeated gadobutrol administration. The molecular structure of gadolinium-based contrast agent preparations may be an essential factor causing SI increase on unenhanced T1-weighted images.Key Points: • Repeated administration of gadobutrol does not lead to increased signal intensity. • Voxel-based whole-brain analysis allows assessment of subtle changes in signal intensity. • Macrocyclic contrast agents in a proven dosage are safe. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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