Non-specific benign pathological results on transthoracic core-needle biopsy: how to differentiate false-negatives?
Objectives: To determine the negative predictive value (NPV) of non-specific benign results from cone-beam CT (CBCT)-guided transthoracic core-needle biopsy (TTNB) and identify predicting factors for false-negative for malignancies.Methods: From January 2009-December 2011, 1,108 consecutive patients...
| Publicado en: | European Radiology Vol. 27; no. 9; pp. 3888 - 3896 |
|---|---|
| Autores principales: | , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2017
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124485410&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124485410 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2017 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124485410 124485410 143991244 NLM28188426 124485410 10.1007/s00330-017-4766-3 NLM28188426 124485410 ppf: 3888 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Non-specific benign pathological results on transthoracic core-needle biopsy: how to differentiate false-negatives? aug: au: Kim, Jung Park, Chang Kim, Hyungjin Lee, Jong Goo, Jin Kim, Jung Im Park, Chang Min Lee, Jong Hyuk Goo, Jin Mo affil: Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine , Seoul National University Medical Research Center , 101, Daehangno, Jongno-gu Seoul 110-744 Korea sug: subj: Lung Neoplasms Pathology Lung Pathology False Negative Results Aged, 80 and Over Specialties, Medical Retrospective Design Needles Male Adult Granuloma Pathology Pneumonia Pathology Aged Tomography, X-Ray Computed Methods Middle Age Female Biopsy Methods Biopsy, Needle Methods Human Aged, 80 & over Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Objectives: To determine the negative predictive value (NPV) of non-specific benign results from cone-beam CT (CBCT)-guided transthoracic core-needle biopsy (TTNB) and identify predicting factors for false-negative for malignancies.Methods: From January 2009-December 2011, 1,108 consecutive patients with 1,116 lung lesions underwent CBCT-guided TTNB using an 18-gauge coaxial cutting needle. Among them, 226 patients with 226 TTNBs, initially diagnosed as non-specific benign, were included in this study. The medical charts, radiological or pathological follow-ups were reviewed to classify false-negative and true-negative results and to identify which variables were associated with false-negatives.Results: Of 226 lesions, 24 (10.6%) were finally confirmed as malignancies and 202 (89.4%) as benign, of which the NPV was 89.4% (202/226). Multivariate analysis revealed that part-solid nodule (PSN) (odds ratio (OR), 3.95; P = 0.022), a biopsy result of 'granulomatous inflammation' (OR, 0.04; P = 0.022), and exact location of needle tip within targets (OR, 0.37; P = 0.045) were significantly associated with false-negatives among initial non-specific benign biopsy results.Conclusion: The NPV of the non-specific benign biopsy was 89.4%. PSN was a significant positive indicator, but a biopsy result of 'granulomatous inflammation' and exact location of needle tip within targets were significant negative indicators for false-negatives.Key Points: • The negative predictive value of the non-specific benign biopsy was 89.4%. • A part-solid nodule is a significant predictor for false-negative biopsy (OR = 3.95). • Pathological diagnosis of granulomatous inflammation is a robust indicator for 'true-negatives'. • Identifying needle tip within target lesions is a significant predictor for 'true-negatives'. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|