Poorly-differentiated colorectal neuroendocrine tumour: CT differentiation from well-differentiated neuroendocrine tumour and poorly-differentiated adenocarcinomas.
Objective: The differentiation of poorly-differentiated neuroendocrine tumours (PD-NETs), well-differentiated NETs (WD-NETs), and adenocarcinomas (ADCs) is important due to different management options and prognoses. This study is to find the differential CT features of colorectal PD-NETs from WD-NE...
| Publicado en: | European Radiology Vol. 27; no. 9; pp. 3867 - 3877 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124485412&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124485412 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2017 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124485412 124485412 144172957 NLM28210802 124485412 10.1007/s00330-017-4764-5 NLM28210802 124485412 ppf: 3867 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Poorly-differentiated colorectal neuroendocrine tumour: CT differentiation from well-differentiated neuroendocrine tumour and poorly-differentiated adenocarcinomas. aug: au: Kang, Ji Kim, Se Han, Joon Kang, Ji Hee Kim, Se Hyung Han, Joon Koo affil: Department of Radiology , Seoul National University Hospital , 101 Daehangno, Jongno-gu Seoul 03080 Korea sug: subj: Adenocarcinoma Neuroendocrine Tumors Colorectal Neoplasms Liver Neoplasms Human Female Diagnosis, Differential Adult Retrospective Design Adenocarcinoma Pathology Cell Transformation, Neoplastic Prognosis Colorectal Neoplasms Pathology Middle Age Aged Male Tomography, X-Ray Computed Methods Aged, 80 and Over ROC Curve Validation Studies Comparative Studies Evaluation Research Multicenter Studies Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Objective: The differentiation of poorly-differentiated neuroendocrine tumours (PD-NETs), well-differentiated NETs (WD-NETs), and adenocarcinomas (ADCs) is important due to different management options and prognoses. This study is to find the differential CT features of colorectal PD-NETs from WD-NETs and ADCs.Materials and Methods: CT features of 25 colorectal WD-NETs, 36 PD-NETs, and 36 ADCs were retrospectively reviewed. Significant variables were assessed using univariate and multivariate analyses. Receiver operating characteristics analysis determined the optimal cut-off value of tumour and lymph node (LN) size.Results: Large size, rectum location, ulceroinfiltrative morphology without intact overlying mucosa, heterogeneous attenuation with necrosis, presence of ≥3 enlarged LNs, and metastasis were significant variables to differentiate PD-NETs from WD-NETs (P < 0.05). High attenuation on arterial phase, persistently high enhancement pattern, presence of ≥6 enlarged LNs, large LN size, and wash-in/wash-out enhancement pattern of liver metastasis were significant variables to differentiate PD-NETs from ADCs (P < 0.05).Conclusions: Compared to WD-NETs, colorectal PD-NETs are usually large, heterogeneous, and ulceroinfiltrative mass without intact overlying mucosa involving enlarged LNs and metastasis. High attenuation on arterial phase, presence of enlarged LNs with larger size and greater number, and wash-in/wash-out enhancement pattern of liver metastasis can be useful CT discriminators of PD-NETs from ADCs.Key Points: • Compared to WD-NETs, PD-NETs more frequently accompany enlarged LNs and metastases. • Metastatic LNs from PD-NETs are significantly larger than those from ADCs. • Hepatic metastases from PD-NETs usually show early enhancement and delayed washout. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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