Feasibility and accuracy of dual-layer spectral detector computed tomography for quantification of gadolinium: a phantom study.
Objectives: The aim of this study was to evaluate the feasibility and accuracy of dual-layer spectral detector CT (SDCT) for the quantification of clinically encountered gadolinium concentrations.Methods: The cardiac chamber of an anthropomorphic thoracic phantom was equipped with 14 tubular inserts...
| Publicado en: | European Radiology Vol. 27; no. 9; pp. 3677 - 3687 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124485432&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124485432 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Sep2017 vid: 27 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124485432 124485432 144181159 NLM28124106 124485432 10.1007/s00330-017-4737-8 NLM28124106 124485432 ppf: 3677 ppct: 10 formats: fmt: @attributes: type: P tig: atl: Feasibility and accuracy of dual-layer spectral detector computed tomography for quantification of gadolinium: a phantom study. aug: au: Hamersvelt, Robbert Willemink, Martin Jong, Pim Milles, Julien Vlassenbroek, Alain Schilham, Arnold Leiner, Tim van Hamersvelt, Robbert W Willemink, Martin J de Jong, Pim A Schilham, Arnold M R affil: Department of Radiology , University Medical Center Utrecht , 3508 GA Utrecht The Netherlands sug: subj: Phantoms, Imaging Elements Analysis Tomography, X-Ray Computed Methods Pilot Studies Heart Reproducibility of Results Human ab: Objectives: The aim of this study was to evaluate the feasibility and accuracy of dual-layer spectral detector CT (SDCT) for the quantification of clinically encountered gadolinium concentrations.Methods: The cardiac chamber of an anthropomorphic thoracic phantom was equipped with 14 tubular inserts containing different gadolinium concentrations, ranging from 0 to 26.3 mg/mL (0.0, 0.1, 0.2, 0.4, 0.5, 1.0, 2.0, 3.0, 4.0, 5.1, 10.6, 15.7, 20.7 and 26.3 mg/mL). Images were acquired using a novel 64-detector row SDCT system at 120 and 140 kVp. Acquisitions were repeated five times to assess reproducibility. Regions of interest (ROIs) were drawn on three slices per insert. A spectral plot was extracted for every ROI and mean attenuation profiles were fitted to known attenuation profiles of water and pure gadolinium using in-house-developed software to calculate gadolinium concentrations.Results: At both 120 and 140 kVp, excellent correlations between scan repetitions and true and measured gadolinium concentrations were found (R > 0.99, P < 0.001; ICCs > 0.99, CI 0.99-1.00). Relative mean measurement errors stayed below 10% down to 2.0 mg/mL true gadolinium concentration at 120 kVp and below 5% down to 1.0 mg/mL true gadolinium concentration at 140 kVp.Conclusion: SDCT allows for accurate quantification of gadolinium at both 120 and 140 kVp. Lowest measurement errors were found for 140 kVp acquisitions.Key Points: • Gadolinium quantification may be useful in patients with contraindication to iodine. • Dual-layer spectral detector CT allows for overall accurate quantification of gadolinium. • Interscan variability of gadolinium quantification using SDCT material decomposition is excellent. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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