Numerical study to indicate the vulnerability of plaques using an idealized 2D plaque model based on plaque classification in the human coronary artery.
Atherosclerosis is one of the leading causes of death in the world. In this study, an idealized 2D plaque model based on plaque classification in the coronary artery is developed. When creating the idealized 2D model for each plaque type (fibrocalcic, FC; fibrofatty, FT; calcified fibroatheroma, CaF...
| Published in: | Medical & Biological Engineering & Computing Vol. 55; no. 8; pp. 1379 - 1388 |
|---|---|
| Main Authors: | , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Springer Nature
Aug2017
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124485675&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124485675 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Aug2017 vid: 55 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124485675 124485675 143981327 NLM27943103 124485675 10.1007/s11517-016-1602-x NLM27943103 124485675 ppf: 1379 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Numerical study to indicate the vulnerability of plaques using an idealized 2D plaque model based on plaque classification in the human coronary artery. aug: au: Lee, Wookjin Choi, Gyu Cho, Seong Choi, Gyu Jin Cho, Seong Wook affil: School of Mechanical Engineering , Chung-Ang University , Seoul South Korea sug: subj: Coronary Arteriosclerosis Physiopathology Atherosclerosis Physiopathology Models, Biological Coronary Vessels Pathology Coronary Vessels Physiopathology Atherosclerosis Pathology Coronary Arteriosclerosis Pathology Computer Simulation Elasticity Stress, Mechanical Models, Anatomic Finite Element Analysis Biomechanics Human ab: Atherosclerosis is one of the leading causes of death in the world. In this study, an idealized 2D plaque model based on plaque classification in the coronary artery is developed. When creating the idealized 2D model for each plaque type (fibrocalcic, FC; fibrofatty, FT; calcified fibroatheroma, CaFA; fibroatheroma, FA; calcified thin-cap fibroatheroma, CaTCFA; thin-cap fibroatheroma, TCFA), the cap thickness and stenosis by diameter were set as variables. In order to establish the correlation between each plaque type and plaque rupture, a numerical simulation was performed and the stress and stress gradient were reviewed to analyze the mechanical behavior. Results show that both the TCFA and CaTCFA plaque types, which have the smallest cap thicknesses of the different types of plaque, showed relatively high stress values in the thin membrane when compared with the FT type. The FT type is considered to be relatively stable since it does not have necrotic core or a thin membrane. With a stenosis rate of 50% and a cap thickness of 60 μm, the TCFA and CaTCFA types showed approximately 11 and 110% higher stress values, respectively, and 679 and 1568% higher negative stress gradient values, respectively. In other words, the plaque types with thin caps, which have weak load-bearing capacities, showed high stress values and high negative stress gradients in the radial direction. It is understood that this result could indicate the possibility of plaque rupture. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|