A novel approach for local abdominal aortic aneurysm growth quantification.

Although aneurysm size still remains the most accepted predictor of rupture risk, abdominal aortic aneurysms (AAAs) with maximum diameter smaller than 5 cm may also rupture. Growth rate is an additional marker for rupture risk as it potentially reflects an undesirable wall remodeling that leads to f...

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Publicado en:Medical & Biological Engineering & Computing Vol. 55; no. 8; pp. 1277 - 1287
Autores principales: Metaxa, Eleni, Iordanov, Iordan, Maravelakis, Emmanuel, Papaharilaou, Yannis
Formato: equations & formulas pictorial research tables/charts Journal Article
Publicado: Springer Nature Aug2017
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Springer Nature
      place: New York, New York
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          Metaxa, Eleni
          Iordanov, Iordan
          Maravelakis, Emmanuel
          Papaharilaou, Yannis
        affil: Institute of Applied and Computational Mathematics , Foundation for Research and Technology - Hellas , Nikolaou Plastira 100, Vassilika Vouton 700 13 Heraklion Greece
      sug:
        subj:
          Tomography, X-Ray Computed Methods
          Vascular Remodeling
          Aorta, Abdominal Pathology
          Aortic Aneurysm, Abdominal Pathology
          Models, Biological
          Aorta, Abdominal Physiopathology
          Aortic Aneurysm, Abdominal Physiopathology
          Disease Progression
          Female
          Computer Simulation
          Radiographic Image Interpretation, Computer-Assisted
          Aged
          Male
          Aortic Aneurysm, Abdominal
          Aorta, Abdominal
          Models, Anatomic
          Human
          Aged: 65+ years
          Female
          Male
      ab: Although aneurysm size still remains the most accepted predictor of rupture risk, abdominal aortic aneurysms (AAAs) with maximum diameter smaller than 5 cm may also rupture. Growth rate is an additional marker for rupture risk as it potentially reflects an undesirable wall remodeling that leads to fast regional growth. Currently, an indication for surgery is an expansion rate >10 mm/year, measured as change in maximum diameter over time. However, as AAA expansion is non-uniform, it is questionable whether measurement of maximum diameter change over time can capture increased localized remodeling activity. A method for estimating AAA surface area growth is introduced, providing a better measure of local wall deformation. The proposed approach is based on the non-rigid iterative closest point algorithm. Optimization and validation is performed using 12 patient-specific AAA geometries artificially deformed to produce a target surface with known nodal displacements. Mesh density sensitivity, range of uncertainty, and method limitations are discussed. Application to ten AAA patient-specific follow-ups suggested that maximum diameter growth does not correlate strongly with the maximum surface growth (R 2 = 0.614), which is not always colocated with maximum diameter, or uniformly distributed. Surface growth quantification could reinforce the quality of aneurysm surveillance programs.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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