Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial.
Purpose: To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.Methods: Fifty-two youth with MS (16.03 ± 2.2 years) were randomized...
| Published in: | Quality of Life Research Vol. 26; no. 9; pp. 2333 - 2350 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
| Format: | research randomized controlled trial Journal Article |
| Published: |
Springer Nature
Sep2017
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124517145&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124517145 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09629343 GPQ jtl: Quality of Life Research issn: 09629343 maglogo: N pubinfo: dt: Sep2017 vid: 26 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 124517145 124517145 143927090 NLM28393317 124517145 10.1007/s11136-017-1571-z NLM28393317 124517145 ppf: 2333 ppct: 17 formats: fmt: @attributes: type: P tig: atl: Impact of an electronic monitoring device and behavioral feedback on adherence to multiple sclerosis therapies in youth: results of a randomized trial. aug: au: Yeh, E. Ann Grover, Stephanie Powell, Victoria Alper, Gulay Banwell, Brenda Edwards, Kim Gorman, Mark Graves, Jennifer Lotze, Timothy Mah, Jean Mednick, Lauren Ness, Jayne Obadia, Maya Slater, Ruth Waldman, Amy Waubant, Emmanuelle Schwartz, Carolyn Grover, Stephanie A Powell, Victoria E Banwell, Brenda L affil: Pediatric MS and Neuroinflammatory Disorders Program, Division of Neurology, Department of Pediatrics, Neuroscience and Mental Health, Hospital for Sick Children Research Institute , Hospital for Sick Children , 555 University Avenue, Rm 6D33 Toronto M5G1X8 Canada sug: subj: Quality of Life Psychosocial Factors Medication Compliance Health Behavior Male Human Multiple Sclerosis Pathology Adolescence Female Validation Studies Comparative Studies Evaluation Research Multicenter Studies Randomized Controlled Trials Funding Source Adolescent: 13-18 years Male Female ab: Purpose: To report the results of a randomized controlled trial using an electronic monitoring device (EM) plus a motivational interviewing (MI) intervention to enhance adherence to disease-modifying therapies (DMT) in pediatric MS.Methods: Fifty-two youth with MS (16.03 ± 2.2 years) were randomized to receive either MI (n = 25) (target intervention) or a MS medication video (n = 27) (attention control). Primary endpoint was change in adherence. Secondary outcomes included changes in quality of life, well-being and self-efficacy. Random effects modeling and Cohen's effect size computation evaluated intervention impact.Results: Longitudinal random effect models revealed that the MI group decreased their EM adherence (GroupxTime interaction = -0.19), while increasing frequency of parental DMT reminder (26.01)/administration (11.69). We found decreased EM use in the MI group at 6 months (Cohen's d = -0.61), but increased pharmacy refill adherence (d = 0.23). Parental reminders about medication increased in MI subjects vs controls (d = 0.59 at 3 months; d = 0.70 at 6 months). We found increases in self-reported adherence (d = 0.21) at 3 but not 6 months, fewer barriers to adherence at three (d = -0.58) and six months (d = -0.31), better physical (d = 0.23 at 3 months; d = 0.45 at 6 months), emotional (d = 0.25 at 3 months) and self-efficacy function (d = 0.55 at 3 months; 0.48 at 6 months), but worse well-being, including self-acceptance (d = -0.53 at 6 months) and environmental mastery (d = -0.42 at 3 and 6 months) in intervention as compared to control patients.Conclusions: Participants receiving MI + EM experienced worsening on objective measures of adherence and increased parental involvement, but improved on some self- and parent-reported measures. MI participants reported improvements in quality of life and self-efficacy, but worsened well-being. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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