The importance of myocardial contractile reserve in predicting response to cardiac resynchronization therapy.
Aim To perform a meta-analysis and systematic review of published data to assess the relationship between contractile reserve and response to cardiac resynchronization therapy (CRT) in patients with heart failure. Methods and results We searched MEDLINE/PubMed and Cochrane for all papers published u...
| Publicado en: | European Journal of Heart Failure. Supplements Vol. 19; no. 7; pp. 862 - 870 |
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| Autores principales: | , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124579037&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124579037 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15674215 JE7 jtl: European Journal of Heart Failure. Supplements issn: 15674215 maglogo: N pubinfo: dt: Jul2017 vid: 19 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 124579037 124579037 124579037 10.1002/ejhf.768 124579037 ppf: 862 ppct: 8 formats: tig: atl: The importance of myocardial contractile reserve in predicting response to cardiac resynchronization therapy. aug: au: Kloosterman, Mariëlle Damman, Kevin Van Veldhuisen, Dirk J. Rienstra, Michiel Maass, Alexander H. affil: Department of Cardiology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700 RB, Groningen, the Netherlands. sug: subj: Cardiac Resynchronization Therapy Heart Failure Publication Bias Computer Terminals Cardiac Patients Systematic Review Data Analysis Odds Ratio Confidence Intervals Randomized Controlled Trials Nonexperimental Studies Study Design Multivariate Analysis Experimental Studies Internal Validity Data Collection Case Studies External Validity Prospective Studies Literature Review Scales Probability Sensitivity and Specificity ab: Aim To perform a meta-analysis and systematic review of published data to assess the relationship between contractile reserve and response to cardiac resynchronization therapy (CRT) in patients with heart failure. Methods and results We searched MEDLINE/PubMed and Cochrane for all papers published up to 26 April 2016, supplemented by manual searches of reference lists from retrieved articles. The search strategy yielded nine observational studies that met our eligibility criteria with a total of 767 patients of which 757 provided data for this analysis. Contractile reserve after dobutamine infusion was present in 496 patients (66%). During follow-up 474 patients (63%) qualified as CRT responders. The presence of contractile reserve was associated with a higher chance of CRT response (odds ratio 4.42, 95% confidence interval 2.15–9.07, P <0.001) using a random-effects model. There was evidence of publication bias. Imputation of missing studies attenuated the association to some extent, but the positive association between contractile reserve and CRT response remained with an odds ratio of 2.42 (95% confidence interval 1.17–5.05, P =0.018). Conclusion The presence of global contractile reserve at baseline, as assessed by dobutamine stress echocardiography, is associated with a higher chance of CRT response in patients with heart failure. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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