Genetic Association Study of KCNQ5 Polymorphisms with High Myopia.
Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-control study of 1563 unrelated Han Chinese subjects...
| Publicado en: | BioMed Research International Vol. 2017; pp. 1 - 8 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
8/13/2017
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=124587748&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 124587748 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 8/13/2017 vid: 2017 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 124587748 124587748 124587748 10.1155/2017/3024156 124587748 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Genetic Association Study of KCNQ5 Polymorphisms with High Myopia. aug: au: Liao, Xuan Yap, Maurice K. H. Leung, Kim Hung Kao, Patrick Y. P. Liu, Long Qian Yip, Shea Ping affil: Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College and Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, Sichuan, China sug: subj: Myopia Familial and Genetic Genetics Polymorphism, Genetic Myopia Diagnosis Refractive Errors Physiopathology Potassium Physiology China Geographic Locations Chinese Persons Nucleotides Logistic Regression Male Female Ophthalmology Eye Diseases Myopia Epidemiology Optometry Research Subject Recruitment Data Analysis Software Odds Ratio Chi Square Test Confidence Intervals Descriptive Statistics Control Group Genotype Alleles Funding Source Male Female ab: Identification of genetic variations related to high myopia may advance our knowledge of the etiopathogenesis of refractive error. This study investigated the role of potassium channel gene (KCNQ5) polymorphisms in high myopia. We performed a case-control study of 1563 unrelated Han Chinese subjects (809 cases of high myopia and 754 emmetropic controls). Five tag single-nucleotide polymorphisms (SNPs) of KCNQ5 were genotyped, and association testing with high myopia was conducted using logistic regression analysis adjusted for sex and age to give Pasym values, and multiple comparisons were corrected by permutation test to give Pemp values. All five noncoding SNPs were associated with high myopia. The SNP rs7744813, previously shown to be associated with refractive error and myopia in two GWAS, showed an odds ratio of 0.75 (95% CI 0.63–0.90; Pemp = 0.0058) for the minor allele. The top SNP rs9342979 showed an odds ratio of 0.75 (95% CI 0.64–0.89; Pemp = 0.0045) for the minor allele. Both SNPs are located within enhancer histone marks and DNase-hypersensitive sites. Our data support the involvement of KCNQ5 gene polymorphisms in the genetic susceptibility to high myopia and further exploration of KCNQ5 as a risk factor for high myopia. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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